Oseltamivir

Question 1

chemistry

Answer 1

antiviral neuraminidase inhibitor
(glycoprotein on virus surface)
prodrug of active metabolite oseltamivir carboxylate

Question 2

clinical

Answer 2

used to treat and prevent infection of influenza A and B

Question 3

side effects

Answer 3

D&V
nausea
dizziness
dry/itchy eyes
dry skin
dry mouth

Question 4

brand name

Answer 4

Tamiflu

Question 5

mechanism of action

Answer 5

virus infects host cells, tries to bud off from plasma membrane to infect other cells
virus remains on host cells by sialic acid receptors on host membrane as needs neuraminidase to cleave sialic acid receptors
oseltamivir mimics sialic acid binding site so binds to neuraminidase on virus
blocks neuraminidase from cleaving sialic acid receptors
prevents virus spreading to infect other cells, therefore dies

Question 6

physiology

Answer 6

neuraminidase activity is important for viral entry into unaffected cells
for release of recently formed virus particles from infected cells
and for further spread of infectious virus in the body
decreases viral shedding and infectivity