Methotrexate Flashcards

1
Q

drug classification

A

antimetabolite
dihydrofolate reductase inhibitor

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2
Q

used to treat

A

wide variety of cancers
severe psoriasis
severe rheumatoid arthritis
juvenile rheumatoid arthritis

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3
Q

brand names

A

metoject
nordimet
otrexup

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4
Q

methods of administration

A

given as a shot under the skin using a pre-filled injection pen
usually in the stomach or the thigh
tablets
liquid

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5
Q

mechanism of action

A

enters tissues and is converted to methotrexate polyglutamate by folylpolyglutamate
competitively inhibits dihydrofolate reductase which inhibits enzymes responsible for nucleotide synthesis
prevents cell division
taken on different day to folic acid to reduce side effects

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6
Q

side effects

A

mucositis
patients should report side effects associated with blood disorders: sore throat, bruising and mouth ulcers

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7
Q

how does it link to the PBL case

A

drug used within maintenance therapy
given once weekly

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