Flucloxacillin Flashcards

1
Q

drug classification

A

narrow spectrum antibiotic
penicillin
B-lactam

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2
Q

chemical structure

A

contains a beta lactam ring
resembles tetra peptide chain

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3
Q

brand name

A

floxapen
fluclox

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4
Q

bioavailability

A

50-70%

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5
Q

used to treat

A

bacterial infection caused by gram positive bacteria

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6
Q

mechanism of action

A

binds to transpeptidase which is a penicillin binding protein inside the bacterial cell wall
inhibits 3rd and last stage of cell wall synthesis
prevents the PBPs from cross-linking the D-ala-D-ala chain on a tetra peptide

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7
Q

what happens when there’s no cross linking in peptidoglycan

A

wall becomes weak
cell lyses occurs by autolytic enzymes such as autolysins
hydrolyse mucopeptide polymers in bacterial cell wall
if they attempt to divide their cell walls will collapse
kill them

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8
Q

side effects for normal penicillins

A

D&V
nausea
skin reactions
hypersensitivity
thrombocytopenia

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9
Q

side effects of flucloxacillin

A

gastrointestinal disorders
allergy presenting as a skin rash
anaphylactic reactions, hypotension, bronchospasm

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