Orthopaedics: Intro and Developmental Diseases Flashcards
What are the 5 functions of bones?
Skeletal support- movement
Protection
Haematopoiesis
Regulation of mineral haemostasis
Fat storage
What is trabecular and cortical bone?
Trabecular (cancellous) and woven bone-
Location- metaphysis, flat bones- dissipates load
Cortical bone-
dense bone or diaphysis, supports weight, protects organs, provides levers
Describe how bone develops?
Intramembranous ossification
Skull and scapula-
undifferentiated mesenchymal cells into osteoblasts
direct production of bone by osteoblasts
Endochondral ossification-
seen in long bones, formation and replacement of cartilage template by bone, increases length
Physis- key structures responsible for longitudinal bone growth
What is bone modelling?
When does it occur?
Ability of bone to change based on strain put on it in the developing animal
Osteoblasts from bone where there was none before, osteoclasts remove bone to alter shape- work together
Replacement of damaged bone
Fracture repair
Prevent accumulation of fatigue damage - microscopic damage
What is Wolff’s law
Primary regulator of bone remodelling
Adaptable- to life and excercise
Adaption-
Increase/Decrease- size/density
How does bone respond to load?
Bone is anisotropic- mechanical properties depend on- size and shape-
cortical thickness, mineralisation, magnitude, direction, rate
Forces- need to be stopped or bone wont recover-
compression, tension, bending, torsion, shearing
With load bones deform
What are the different types of bone deformation?
Elastic deformation-
with loading and unloading the bone deforms then returns to the original shape
stimulates modelling
Plastic deformation-
with loading and unloading the bone deforms and doesn’t return to original shape-
microcracks, cyclic fatigue, incomplete fractures
What are the practical implications of bone deformation?
Complete bone failure
Weakening of normal bone-
plastic deformation and repetitive loading = stress fractures
abnormal matrix- metabolic, neoplasia
What can cause the failure of a normal bone?
What are stress fractures and where do they commonly occur?
Single supra-physiological load- kick wound, hit by car
Internal truama-
Foot planted and body twists- stuck in hole
Stress fractures- fracture of weakened bone (cannot keep up)
racehorses- MCIII/MTIII condylar fracture, dorsal metacarpal disease
greyhounds- acetabulum, central tarsal bone
What is dorsal metacarpal disease?
- Primary racing force on lateral side
- Primary galloping side on medial side
- Classical training give poor adaption to race- increased bone on medial side
- Modified training gives better density and adaption to race
- Grey hounds race anticlockwise- more weight on left- increased bone
What neoplasia can affect bones?
Osteosarcoma
Haemangiosarcoma
Multiple myeloma
Chondrosarcoma
Bacterial osteomyelitis
What causes metabolic bone disease?
Related to the metabolism of calcium and phosphorus
Controlled by:
vitamin D
PTH
Calcitonin
The mineral content of bone
PTH abnormality
Vit D deficiency
Paraneoplastic
What are developmental orthopaedic diseases?
Group of diseases
Cause musculoskeletal problems- various syndromes, age predisposition
Multifactorial
Disturbance in development- cartilage, bone
What are the different regions in a growth plate?
Resting cartilage
Proliferative cartilage
Hypertrophic cartilage
Calcifying cartilage
Secondary spongiosa
How can disturbances in endochondral ossification lead to developmental orthopaedic disease?
Physeal growth plate-
abnormal deposition of matrix, abnormal mineralisation, poor conversion to bone, retention of cartilage
Result- slow uneven growth
Articular-epiphyseal CC-
abnormal deposition of the matrix, abnormal mineralisation, retention of cartilage
Result- slow growth, uneven growth, cartilage flaps