Orthomollecular Ingredients and Mushrooms Flashcards
What is meant by Orthomollecular?
The right mollecules in the right amounts
Are orthomollecular compounds essential?
No, they can be synthesised in the body
Give 4 examples of orthomollecular compunds?
C0Q10
Alpha-lipoic acid
Glucosamine
Chondroitin Sulphate
What is orthomollecular medicine?
The practise of preventing and treating disease by providing the body with optimal amounts of the substances that it already produces.
Why is CoQ10 so important?
It is present in all mitochondria and plays a crucial role in ATP production
What is CoQ10 also known as?
Ubiquinine
Name 3 factors that might reduce CoQ10.
Ageing
Statins
Certain disease states (e.g. cardiovascular)
Name 5 food sources of CoQ10
- Peanuts and pistachios
- Sesame seeds
- Olive Oil
- Oranges
- Strawberries
- Avocado
- Broccalli and Cauliflower
- Meat and Poultry
- Fish (herring, mackerel, trout)
- Eggs
Name 4 functions of CoQ10
- Energy production- needed for the electron transport chain
- Antioxident-
-A potent fat soluble anti-oxident, it inhibits the peroxidation of cell membrane lipids.
-It neutralises free radicals produced by the mitochondria - CV Health-
-Crucial for cardiac muscle function
-Protects against endothelial damage with helps with atherosclerosis
-Reduces LDL oxidation
-Increases superoxide dismutase which preserves the activity of Nitric Oxide. - Peridontal Health-
-Diseased gums have much lower levels of CoQ10
-This is thought to be because of the oxidative stress caused by gingevalis which triggers mitochondrial dysfunction
Which enzyme, also responsible for CoQ10 production is blocked by statins?
HMG-CoA reductase
What is the metabolic pathway responsible for the production of cholesterol and CoQ10 called?
The Mevalonate pathway
What is Alpha Lipoic Acid?
A naturally occuring short-chain fatty acid
What are the 2 forms of alpha lipoic acid?
Which one is more potent?
R-form (natural)
S-form (synthetic)
The R form is nearly 10 x more potent.
How does Alpha Lipoic Acid act as an antioxident?
-It is a fat and water soluble antioxidant (works intracellularly and extracellularly)
-It is anti-inflammatory
-It can regenerate other antioxidants (e.g. E, C, glutathione and CoQ10)
-It upregulates glutathione
-Protects spermatozoa from oxidation.
Which diseases can ALA be used theraputically for?
-Infertility (600 mg daily)
-Diabetes, PCOS (improves insulin sensitivity)
-AZ (slows decline 600 mg daily for 1 + year)
-MS
-Chronic fatigue
-Peripheral neropathy-reduces oxidation of the myelin sheath
-Heavy metal detox-it can chelate iron, mercury, copper, lead and zinc.
Name 5 food sources of ALA
Brassicas, spinach, potato, carrots, beets, tomatos, peas, brewer’s yeast.
Why is ALA crucial for energy production?
It is one of the key coenzymes required to convert carbohydrates into engery in the kreb cycle.
By what mechanisms can ALA promote weightloss?
-Reduces the oxidative stress that promotes weight-gain
-Influences AMPK (activated protein kinase) to reduce appetite
-Increases energy expenditure and reduces fat synthesis
Dosage 1,800 mg per day.
What should we be mindful of when prescribing ALA supplementation?
Must be taken on an empty stomach to optimise bioavailability
Competes with biotin for activation across cell membranes
Can increase hypglycaemia in medicated diabetic patients. Glucose levels must be monitored.
What is Glucosamine?
What is it’s function in the body?
An aminosugar naturally present in body tissues with high concentrations in joints and cartialage.
Required for the synthesis of glycoprotiens, glycolipds and glycominoglycans (GAGS) also known as mucopolysaccharides. These are an important structual compontent of-
-tendons
-ligaments
-cartialage
-synovial fluid
-mucous membranes
-structures in the eye, blood vessels and heart valves.
How can Glucosamine be helpful in IBD and intestinal permeability?
NAG Supports the GI epithelial barrier by enhancing the function of mucin (a group of protiens found in mucous that form a barriet and prevent microbial overgrowth)
Also reduces the biofilm formation associated with IBD
By what mechanism can Glucosamine be helpful in the treatment of osteoarthritis?
-Stimulates metabolism of chondrocytes in the joint that slows down degeneration and prevents joint space narrowing
-Decreases inflammation by inhibiting cytokines (e.g. interleukin-1)
-Pain reduction, comaprable to NSAIDS
What can glucosamine be combined with the enhance it’s effects in the treatment of Oseoarthritis?
Chondroitin and MSM
Name 3 properties of Chondroitin Sulphate
- It is a type of glycosminoglycan
- it is a major component of many connective tissues
- Thickens synovial fluid, this provides resistance to compression.
By what mechanisms can chondroitin sulphate be useful in the treatment of osteoarthritis?
Protects cartialage from degradation by..
-reducing degradative enzymes
-decreasing inflammation (inhibits COX 2)
-increases hyaluronic acid synthesis-enhancing joint lubrication
What is MSM
Methyl Sulfonlmthane is a source of sulphar used by plants to create the amino acids cysteine and methionine.
Name 5 food sources of MSM
- Green leafy vegetables
- Alfalfa sprouts
- Algae
- Fruit and vegetables
- Grains
- Cow’s milk
By what mechainisms can MSM help in Osteoarthritis?
-It can reduce pain and swelling and restore joint function
-Anti-inflammatory-inhibits the secretion of inflammatory cytokines
-Sulphur s found in cartiallage
Dosage 500 mg 3 x per day
How can MSM improve CV health?
-Reduces homocysteine levels (acts as a methyl donar)
-Reduces lipid peroxidation (thus protecting the vascular endothelium)
Dosage 3 g per day.
How can the use of MSM be useful to treat allergies?
It acts as an immune modulator, down regulating inflammatory cytokines
What are 2 properties of Betaine?
It’s chemical form is trimethyl glucine (TMG). This can be formed from choline (tetramenthyl glycine)
TMG serves as a methyl donor, faciliating the convertion of homocysteine to methionine
What are optimal blood levels of homocystien
Below 9 micrograms