organs and cells of immune system Flashcards
what happens in the primary lymphoid organs?
cells of immune system develop ( production and maturation)
what are the primary lymph organs?
bone marrow and thymus
what happens in the secondary lymphoid organs?
cells of immune system function/interact with antigens
what are the secondary lymph organs?
lymph nodes spleen tonsils adenoid RE system
how are secondary and primary connected?
blood and lymphatic vessels
where is bone marrow found?
medullary cavity of long bone
hematopoietic stem cells aka
CD34+ cells
where are HP stem cells found and what do they give rise to?
bone marrow
cells of immune system and blood cells
what dictate what cell is formed from HP stem cells?
cytokines and growth factors
when HP cell becomes myeloid stem cell what can it give rise to?
macrophages/monocytes granulocytes eosoniphil RBC platelets
when HP cell becomes lymphoid stem cell what can it give rise to?
T and B cells
NK cells
what is thymus derived from?
endoderm = 3rd pharyngeal pouch
ectoderm = 3rd brachial cleft
mesenchymal element
where is thymus located?
anterior mediastinum
what connects 2 lobes of thymus?
isthmus
what occurs in thymus?
T cell maturation and differentiation (positive and negative selection)
positive selection
T cell can bind to mhc class I / ii with at least weak affinity
negative selection
if T cell bind to / recognize self –> apoptosis
if there’s an issue with thymus what’s affected?
t cells
what surrounds lymph node?
fibrous capsule
what color is spleen and where is it located?
left upper quadrant of abdomen
brown
what’s the function of the spleen?
RBC metabolism and blood borne infections
what are the cells if the innate IS?
pmns
monocytes/MQs
what are the cells of the specific / adaptive IS?
lymphocytes ( T,B cells)
PMNs are
the Phils
baso
eosino
neutro
when are neutrophils present?
bacterial infections
when are eosinophils present?
parasitic / allergic run
when are basophils present?
mast cells in tissue stimulated by allergens
pmns aka
polymorphonuclear leukocytes
B cell receptors
IgD IgM
B cell effectors
plasma cell ( makes IgM IgG IgA)
B cells recognize
protein/polysac antigens extracell antigens (no MHC)
B cells
present antigens to t cells
immature B cell has ___ and mature B cell has ___
CD19
CD20
T cell receptors
alpha beta
gamma delta
T cells are ..
cd4+ or cd8+
T helpers
cd4+ recognize mhc class ii
t cytotoxic
cd8+ recognize mhc class i
all T cells have .
cd3
T cells can recognize only
protein
T cell effectors
cytokines : Th1 and Th2
