hypersensitivity Flashcards
type I hypersensitivity
immediate hypersensitivity
allergic reaction from reexposure
type I hypersensitivity def
exaggerated immune response that causes tissue damage and can kill
reqs for type i
contact with allergen
priming/sensitizing dose
ige production
reexposure
what are results of hypersensitivity I ?
epi damage edema SM spasms leukocyte infiltration mucus secretion
what IG mediates type I?
igE
in type I what takes up the allergen
APC
Th2 release ___ which is required for what?
IL4 required for isotope switching to IgE
what are the preformed mediators in type I granules?
histamine
heparin (proteoglycan)
tryptase chemise and cathepsin
serotonin
histamine roles
constricts SM, intestine and brinchioles
vasodilation –> fluid to tissue –> mucosal swelling
what are the newly formed mediators of type I?
leukotrienes
Th2 cytokines
thromboxane
platelet activation factor
what does type I cause in the GIT?>
diarrhea
vomitting
cramping
what does type I cause in the skin?
urticaria
angioedema
itching
what does type I cause in the airway?
wheezing
sneezing
asthma
rhinitis
type I causes systemic vasodilation and SM muscle contraction resulting in what?
bronchiole constriction
edema
shock
type ii hypersenstiivity aka
cytotoxic antibody hypersensitivity
type ii involves which immunoglobulins ?
Igm and igg
examples of type ii
transfusion of RBCs and hemolytic disease in newborns
type iii aka ( 2)
immune complex formation and ag-ab immune complexes igg mediated
what normally removes immune complex ?
mononuclear phagocytes system
what is chemotactic for neutrophils and a mast cell activator?
C5a
how long does it take for a type iii hypersensitivity to occur?
4-8 hours
immune complex mediated disease
persistent infections
autoimmune disease
inhalation of antigenic material
what persistent infections of immune complex mediated diseases?
malaria
viral hepatitis
subacute endocarditis
glomerulonephritis
what autoimmune diseases of immune complex mediated diseases?
SLE
RA
Polymyositis
what inhalation of antigenic materials of immune complex mediated diseases? ( I know q doesn’t make sense I don’t feel like coming up with something that does )
farmers lung
pigeon fanciers lung
type iv hypersenstiivity aka
cell mediated / delayed
when does type iv arise?
24-72 hours after exposure
types of type iv
contact dermatitis
tuberculin rxn
granulomatous rxn
type iv lesion characterized by?
induration and erythema
what cell ivovled in type iv>
th1
examples of type I aka anaphylactic
allergic asthma
hay fever
examples of type ii aka cytotoxic
erythroblastosis
fetalis
goodpasture’s nephritis
examples of type iii aka immune complex
see farmers lung disease
examples of type iv aka delayed
tuberculin
poison ivy
granuloma
