HLA and Antigen presentation Flashcards
1
Q
antigens
A
molecules that induce immune response
2
Q
epitope
A
part of Ag
3
Q
mhc aka
A
major histocompatibility complex
4
Q
what is mhc
A
part of multiple loci coding for molecules that reject grafts and play role in signaling between lymphocytes and APC
5
Q
hla job
A
present ags to T cells
6
Q
class I mhc
A
hla a b c
7
Q
class ii mhc
A
hla dp dq dr
8
Q
class iii
A
non histocompatibility genes
9
Q
how are hla classes organized on chromosome
A
ii –> iii –> i
10
Q
where can we find class I ?
A
almost all nucleated cells
11
Q
where can we find class ii?
A
APCs
12
Q
what cells don’t have mhc class I ?
A
brain placenta sperm RBCs
13
Q
hla class I and ii structure
A
I = I pp alpha ii = 2 pp alpha and beta
14
Q
if exogenous ag then …
A
class ii
15
Q
if endogenous ag then …
A
class I
