Organization of Isocortex Flashcards

1
Q

Characteristic of cell layers in primary sensory areas

A

Dense small cells in #4

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2
Q

Characteristic of cell layers in primary motor

A

Betz cells in #5

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3
Q

Relay nuclei in thalamus projects to

A

3b-4

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4
Q

Intralaminar nuclei in thalamus project to

A

All but 4

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5
Q

5 traits of stellate cells

A
  1. Spiny
  2. Star shaped w round soma
  3. Found in layer 4
  4. Arborize in multiple directions close to soma
  5. Axon stay in cortex, projecting to 2-3
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6
Q

Betz cells are?

A

Large pyramidal cells

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7
Q

Pyramidal cell that project laterally go…

A

to brother region

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8
Q

Pyramidal cells usually project to

A

1 layer

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9
Q

4 subcortical regions that pyramidal cells project to

A

Basal ganglia
thalamus
brainstem
spinal cord

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10
Q

Corticocortical pyramidal cells are found in layers

A

2, 3, 5

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11
Q

Caliosal pyramidal cells are found in layers

A

3, 5

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12
Q

Cortistriatal pyramidal cells are found in layer

A

5

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13
Q

Cortifugal pyramidal cells are found in layer

A

5

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14
Q

Corticothalamic pyramidal cells are found in layers

A

5, 6

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15
Q

Corticofugal inclues 4 destinations

A

Tectum
Pons
Medulla
Spinal Cord

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16
Q

Intrinsic pyramidal vertical axon collaterals do what

A

arborize in the same area as it’s dendrites

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17
Q

Intrinsic pyramidal horizontal projections do what

A

Stay in same layer
Can travel up to 10mm
Bring the layer together in patchy connections

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18
Q

What is the major source of input to the LGN

A

V1 responding about visual info

19
Q

Non-spiny neurons are always

A

inhibitory

20
Q

4 types of non-spiny cells

A
  1. Basket cells
  2. Chandelier cells
  3. Neurogliaform cells
  4. Double bouquet cells
21
Q

Only cells in layer 1 are

A

non-spiny cells

22
Q

Basket cells terminate on

A

Cell bodies and proximal dendrites

23
Q

Chandelier cells terminate on

A

Axon hillock of pyramidal cells

24
Q

Neurogliaform cells terminate on

A

Distal dendrites of pyramidal cells

25
Q

Double bouquet cells terminate on

A

distal dendrites of other non-spiny cells

26
Q

Calcium binding protein of chandelier cells

A

Parvalbumin

27
Q

Calcium binding protein of Double bouquet cells

A

Calbindin

28
Q

Calcium binding protein of neurogliaform cells

A

Calbindin

29
Q

Calcium binding protein of double bouquet cells that mostly project to other non-spiny cells

A

Calretin

30
Q

Neurogliaform dendrites arborize

A

close to soma

31
Q

Double bouquet cell dendrites arborize

A

up and down

32
Q

The most powerful non-spiny cell is…

A

Chandelier cells

10 axon terminals packed close together synapsing on axon hillock

33
Q

2 ways to subdivide non-spiny cells

A

Neuropeptides contained

CBPs

34
Q

Basal nucleus of Meynert projects to? with? disfunction found in?

A

throughout cortex
Ach
Alzheimer’s

35
Q

Medial septum and diagonal band of Broca projects to? with? disfunction found in?

A

hippocampus
Ach
Alzheimer’s

36
Q

Substantia nigra projects to? with? disfunction found in?

A

Striatum
Dopamine
Parkinson’s

37
Q

VTA projects to (3)? with? Disfunction found in?

A

NA, hippocampus, cortex
Dopamine
Schizophrenia

38
Q

Locus coeruleus projects to? with? Disfunction found in?

A

Most of brain
Norepinephrine
Panic disorder

39
Q

Raphe nuclei projects to? with? Disfunction found in?

A

Throughout brain
5HT
Depression

40
Q

Cortical feed forward to layers

A

3, 4

41
Q

Cortical feedback to layers

A

All but 4

42
Q

Corcticolateral input found in layers

A

All

43
Q

Location of spiny stellate cells and project to layers?

A

4

to 2, 3

44
Q

Location of pyramidal cells and project to layers

A

mainly 2, 3, 5, 6

to any layer where it arborizes