Organisms List

Question 1

Mycoplasma pneumonia

Answer 1

> Virulence Factor - mimic host cell surface
- no peptidoglycan
- PM contain sterols
- deficient with biosynthetic pathways
Disease - walking pneumonia (ID50 = 100)
Reservoir/Vector - human parasite
Gram negative
Treatment - N/A

Question 2

Chlamydia

Answer 2

> Virulence Factor - inclusion cell bodies 
  - OIP
  - no peptidoglycan
  - EB = attach
  - RB = reproduce 
> Disease - chlamydia 
> Reservoir/Vector - human reservoir/animal vector
> Gram negative 
> Treatment - antibiotics

Question 3

Borrelia (spirochete)

Answer 3

> Virulence Factor - evade host defense
  - humans not primary host
  - deer required for reproduction
> Disease - lyme disease 
> Reservoir/Vector - rodent/tick
> Gram negative 
> Symptoms:
  - bulls eye rash
  - neurologic abnormalities 
  - carditis
  - arthritis 
> Treatment:
  - antibiotics 
  - tick control

Question 4

Borrelia (spirochete)

Answer 4

> Virulence Factor - invades hast defense
> Disease - relapsing fever 
> Reservoir/Vector - rodent/tick 
> Gram negative 
> Symptoms:
  - less severe than lyme disease
  - recurring fever 
> Treatment:
  - antibiotics 
  - tick control

Question 5

Treponema pallidum (spirochete)

Answer 5

> Virulence Factor - evade host defense
Disease - syphilis (venereal & congenital)
Reservoir/Vector - human
Gram negative
Symptoms:
- chancre(stage occur multiple years after initial chancre)
- variable rash (stage 2 syphilis - rash on palm of hand)
Treatment:
- antibiotics into stage 2
- sexual education

Question 6

Leptospira (spirochete)

Answer 6

> Virulence Factor - evade host defense
> Disease - leptospirosis 
> Reservoir/Vector - dogs/rats 
  - mucous contacts urine 
  - contaminated water
> Gram negative 
> Symptoms:
  - muscle ache
  - fever
  - meningitis
  - renal failure
  - HA
> Treatment - doxycycline

Question 7

Rickettsia prowazekii/typhi

Answer 7

> Virulence Factor - reproduce in phagocytes 
  - OIP
  - no glucose as source of energy
> Disease - typhus 
> Reservoir/Vector - epidemic = lice/endemic = flea 
> Gram negative 
> Symptoms:
  - fever
  - HA
  - muscle pain
  - rash
  - photosensitive 
> Treatment:
  - antibiotics 
  - avoid lice/flea

Question 8

Rickettsia rickettsii

Answer 8

> Virulence Factor - reproduce in phagocytes 
> Disease - rocky mountain spotted fever
> Reservoir/Vector - rodents/tick transmission
> Gram negative 
> Symptoms:
  - HA
  - fever
  - rash
  - heart/lung/kidney failure
> Treatment:
  - antibiotics 
  - avoid ticks

Question 9

Neisseria meningitidis

Answer 9

> Virulence Factor - capsules; fimbriae
  - airborne/respiratory droplet transmission
> Disease - meningitis 
> Reservoir/Vector - mucous membrane of mammals
> Gram negative 
> Symptoms: 
  - HA
  - confused 
  - stiff neck
> Treatment:
  - antibiotics 
  - vaccine

Question 10

Neisseria gonorrhoeae

Answer 10

> Virulence Factor - Opa protein; block Th cell proliferation
  - block complement protein activation
> Disease - gonorrhea 
> Reservoir/Vector - mucous membrane of mammals
> Gram negative
> Symptoms:
  - endocarditis
  - meningitis
  - pus discharge
  - pelvic inflammatory disease
> Treatment - fluoroquinolones 
  - cephalosporins more commonly used now