Oral PK - 4

Question 1

What is F

Answer 1

Fraction of drug absorbed into the systemic system.
F can range to 0-1

F =1 for IV

Question 2

Why is it technically wrong to use bioavailability and F interchangeably?

Answer 2

bioavailability is the rate of absorption and F is just the fraction that reaches systemically.

Question 3

___ delays and reduces themagnitude of the peakcompared with that seen following an equal IV bolus dose.

Answer 3

absorption

Question 4

what is ka?

Answer 4

1st order absorption rate constant

Question 5

when ka is less tham kel…

Answer 5

adsorption rate limits elimination

Question 6

when ka decreases (slower rate of absorption)
* ___ tpeak
* decreases ___
* bioavailability and CL are ___
* AUCs are ___

Answer 6

• delays
• Cmax
• unchanged
• identical

Question 7

lag time of absorption

Answer 7

the time between administration and start of absorption

Question 8

what can alter lag time

Answer 8

• disintegration/dissolution
• gi motility
• blood flow
• drug transport

Question 9

factors that affect F

Answer 9

• dissolution
• gut wall permeation
• active trasport
• metabolism
• biliary excretion

Question 10

Cmax, tpeak, and F are primary PK parameters assessed for ____

Answer 10

bioequivalence

Question 11

absolute bioavailability

Answer 11

F = (AUCpo/DOSEpo)/(AUCiv/DOSEiv)