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Reagan Smith
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Decks in this class (14)
IV Bolus - 1
Definitionpharmacokinetics pk,
Definitionoptimal drug therapy,
Definitioniv bolus
35
cards
Drug Distribution - 2
Passive diffusion ___ concentrati...,
Paracellular transport is for hyd...,
Facilitated diffusion down concen...
36
cards
Constant rate regimen -3
Constant rate regimenthe drug is ...,
Constant rate regimenconstant pla...,
Why constant rate regimeniv bolus...
15
cards
Oral PK - 4
What is f,
Why is it technically wrong to us...,
___ delays and reduces the magnit...
11
cards
Hepatic Drug Metabolism - 5
Blood flows out of the liver thro...,
Bile composition and function,
Hepatocytes for drug metabolismhe...
23
cards
F/CL - 6
Absolute vs relative bioavailability,
Example if the absolute bioavaila...,
Oral bioavailability f auclarger ...
16
cards
Bioavailability and Clearance - 7
Total clearance is equal to,
Extraction ratio e,
Q represents
7
cards
Multiple Dose PK/dosing regimen
Less frequent dosing ie larger le...,
Larger dosing interval t leads to...,
T or f higher dose is expected to...
6
cards
Multicompartmental PK
One compartment model the body ac...,
Why do we need a multi compartmen...,
The two compartment model is ___ ...
16
cards
Noncompartmental PK analysis
Mrt of a drug would mean the ___ ...,
Auc superposition principleafter ...,
One compartment modelmrt approach...
10
cards
Metabolite PK
Metabolites can affect pk of a __...,
What is the metabolite of zidovudine,
Most effects of metabolites are _...
14
cards
Transporters
Example of efflux transporter,
Uptake transporters 2 oatp organi...,
Oatp organic ___ trasporting prot...
28
cards
Biologics PK handout
Biologics generally derived from ...,
Examples of biologics,
Monoclonal antibodies target spec...
31
cards
Nonlinear Pharmacokinetics
Nonlineaer pk drug concentrations...,
Examples of saturable processes g...,
Absorption mechanisms ___ transpo...
18
cards
More about
PHRM 835
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