Multiple Dose PK/dosing regimen

Question 1

Less frequent dosing (i.e., larger 𝜏) leads to a ___ accumulation index (Rac)

Answer 1

smaller

Question 2

Less frequent dosing (i.e., larger 𝜏) leads to ___ fluctuation

Answer 2

greater

Question 3

T or F: Higher dose is expected to show greater drug accumulation (i.e., higher accumulation index)

Answer 3

False

Frequent drug administration leads to more accumulation

Question 4

Concentration that gives AUCss,0- 𝜏
when maintained for 𝜏

Answer 4

Css,ave

Question 5

Same amount of dose administered per unit time will lead to the ___ Css,ave.

Answer 5

Same

Question 6

Oral multiple dosing has to include ___

Answer 6

F (bioavailability)