Bioavailability and Clearance - 7 Flashcards
1
Q
total clearance is equal to …
A
hepatic clearance plus renal clearance
2
Q
Extraction ratio (E)
A
- A fraction of drug eliminated by a drug-eliminating organ during
single pass - Efficiency of a drug-eliminating organ to eliminate a drug
- Values range from 0 to 1
3
Q
Q represents
A
the blood flow to the organ
4
Q
organ clearance is equal to
A
blood flow (Q) x extraction ratio (E)
5
Q
organ clearance is equal to
A
blood flow (Q) x extraction ratio (E)
6
Q
Qhepatic =
A
0.7 L/min
physiological value
7
Q
Low Ehepatic drug
CLhepatic equals
A
fraction of unbound drug (fu) x CLint
