Oral Conscious Sedation I Flashcards
Sedative agents cross what barrier?
Blood-brain
Cause delayed gastric emptying.
Scleroderma and Amyloidosis
Fraction of the drug that reaches the systemic circulation.
Bioavailability
Can you titrate oral meds?
No- only IV
These molecules diffuse more readily.
Nonpolar, lipid-soluble molecules
Diffusion where molecules move from high to low concentration.
Passive diffusion
Ions pair up to form a neutral complex that can enter the cell by passive diffusion.
Ion pair transport
Engulfment by the cell membrane/internalization.
Pinocytosis
These bind to the drug.
A high degree of binding to these will keep the drug in the body longer, and the drug will have a greater effect.
Plasma proteins
Lipid soluble drugs stay in the body of ____ people longer.
Fat
Well-perfused organs.
Brain, heart, liver, kidneys
Metabolism involves making drugs polar or nonpolar?
polar, water-soluble so they can be excreted
Where most agents are metabolized.
Liver
Phase I reactions involve
Oxidation
Reduction
Hydrolysis
(Breaking down the drug).
Phase II reactions
Conjugation