Chronic Pain Control Flashcards
Nerve disorder where non-nociceptive stimuli elicit pain.
Pain is sharp, and rapid onset.
Often associated with “trigger points” around the affected nerve distribution.
Neuralgia
Another name for trigeminal neuralgia.
Tic delareoux
When systemic disease causes neural pain.
Neuropathy
Using too much of this can mimic MS bc of lack of Vitamin B12
Nitrous
Diabetics have this neural pain.
Neuropathy.
Inflammation of a nerve.
Neuritis
A pain disorder resulting from a NORMAL response to localized, irritative, non-neural disease.
Neuritis
Types of neurotransmitters that cause pain.
1) Excitatory Amino Acids (EAA’s).
2) Tachykinins
Examples of Tachykinins
Substance P
Neurokinin A and B
Substance P is what kind of pain NT?
Tachykinin
Types of EAA receptors
AMPA and NMDA
EAA receptors that bind glutamate to mediate “First Pain.”
AMPA Receptors
EAA receptors that bind aspartate to mediate “second pain.”
NMDA Receptors
Rapid and transient pain
First Pain
Delayed and prolonged pain.
Second Pain
Types of Excitatory Amino Acids that cause pain.
Glutamate and Aspartate
These inhibit the EAA receptors.
Opioids
Inhibit Tachykinin receptors.
Tricyclic antidepressants.
Inhibit Phospholipase A.
Corticosteroids
Side effects of this is adrenal suppression.
Corticosteroids
May cause hyperglycemia.
Corticosteroids
Topical agent that depletes Substance P in the skin and mucosa.
Capsaicin
Increases the effects of GABA to produce analgesia.
Baclofen
Receptors where opioids bind.
Kappa
