Oral Analgesics Part I Flashcards
Cuts Arachidonic Acid out of the cell membrane.
Phospholipase
This pathway makes prostaglandins from Arachidonic Acid.
Cyclooxygenase pathway
Peripheral Analgesics
1) Acetaminophen
2) NSAIDs
Inhibits COX-3.
Anti-pyretic and Analgesic
NOT anti-inflammatory and does NOT inhibit platelet aggregation.
Acetaminophen
Does Acetaminophen cross the placenta?
Yes
Older people get to toxic drug levels more quickly because these organs aren’t working as well.
Kidneys
NSAIDs and Acetaminophen are analgesics, but only these are anti-inflammatory.
NSAIDs.
Maximum Acetaminophen daily dose.
4 g/day
Ceiling Effect pertains to which drugs?
NSAIDs
What is the ceiling effect?
NSAIDs are analgesic below 400 mg, and Anti-inflammatory over 400 mg.
Samter’s Triad
Asthma
Aspirin allergy
Nasal Polyps
Samter’s Triad increases your risk of bronchospasm with these drugs.
NSAIDs
Common adverse effect of NSAIDs
Stomach ulcers
NSAIDs cause premature closure of this in the fetus.
Ductus arteriosus
Ductus arteriosus
Connects the pulmonary artery to the aorta.
Overdose of NSAIDs (particularly ASPIRIN) in kids causes this.
Reyes Syndrome
A sign of NSAID overdose.
Tinnitus
An NSAID for arthritis.
Indomethacin
NSAID associated with risk of Leukemia.
Indomethacin
Brand names made of Ibuprofen.
Motrin and Advil
Dose of Ibuprofen for analgesia.
200-400 mg
Dose of Ibuprofen for Anti-inflammatory effects.
600-800 mg
NSAID associated with abnormal fetal limb development.
Etodolac
NSAID that inhibits COX2
Celecoxib
