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Anesthesia > Oral Analgesics Part I > Flashcards

Oral Analgesics Part I Flashcards

1
Q

Cuts Arachidonic Acid out of the cell membrane.

A

Phospholipase

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2
Q

This pathway makes prostaglandins from Arachidonic Acid.

A

Cyclooxygenase pathway

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3
Q

Peripheral Analgesics

A

1) Acetaminophen

2) NSAIDs

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4
Q

Inhibits COX-3.

Anti-pyretic and Analgesic

NOT anti-inflammatory and does NOT inhibit platelet aggregation.

A

Acetaminophen

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5
Q

Does Acetaminophen cross the placenta?

A

Yes

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6
Q

Older people get to toxic drug levels more quickly because these organs aren’t working as well.

A

Kidneys

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7
Q

NSAIDs and Acetaminophen are analgesics, but only these are anti-inflammatory.

A

NSAIDs.

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8
Q

Maximum Acetaminophen daily dose.

A

4 g/day

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9
Q

Ceiling Effect pertains to which drugs?

A

NSAIDs

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10
Q

What is the ceiling effect?

A

NSAIDs are analgesic below 400 mg, and Anti-inflammatory over 400 mg.

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11
Q

Samter’s Triad

A

Asthma

Aspirin allergy

Nasal Polyps

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12
Q

Samter’s Triad increases your risk of bronchospasm with these drugs.

A

NSAIDs

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13
Q

Common adverse effect of NSAIDs

A

Stomach ulcers

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14
Q

NSAIDs cause premature closure of this in the fetus.

A

Ductus arteriosus

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15
Q

Ductus arteriosus

A

Connects the pulmonary artery to the aorta.

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16
Q

Overdose of NSAIDs (particularly ASPIRIN) in kids causes this.

A

Reyes Syndrome

17
Q

A sign of NSAID overdose.

A

Tinnitus

18
Q

An NSAID for arthritis.

A

Indomethacin

19
Q

NSAID associated with risk of Leukemia.

A

Indomethacin

20
Q

Brand names made of Ibuprofen.

A

Motrin and Advil

21
Q

Dose of Ibuprofen for analgesia.

A

200-400 mg

22
Q

Dose of Ibuprofen for Anti-inflammatory effects.

A

600-800 mg

23
Q

NSAID associated with abnormal fetal limb development.

A

Etodolac

24
Q

NSAID that inhibits COX2

A

Celecoxib

Anesthesia (11 decks)

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