Opportunistic viral infections Flashcards
3 types of acquired immunocompromise
transplant
immunosupp
AIDS
when do infections start in HIV
when CD4 < 200
how does immunosuppression differ in different types of transplant
haematological - tapered down
organ - for life
timeline and cause of infection after transplant
<4w - inf from donor
1mo -12 mo - reaction inf/opportunistic
>12 mo - comm. acq inf
some viruses that have a reactivation time < 1mo after HSCT
HSV 1/2
some viruses that have a reactivation time >1mo after HSCT
VZV
EBV
CMV (<6mo)
pain on swallowing following a liver transplant
HSV
what increases risk of CMV activation within 6mo of solid organ transplant
donor +ve and recipient -ve
how is CMV reactivation prevented and treated in solid organ transplant
prevention = 100 days vangancyclovir Tx = gancyclovir
what increases the risk of CMV reactivation within 6mo of of HSCT
donor -ve and recipient +ve
how is CMV reactivation treated in HSCT
foscarnet
never give ganciclovir in HSCT
which respiratory viruses are associated with increased risk of complications in the immunocompromised
influenza A/B
parainfluenza
adenovirus
RSV
what complications would you be wary of in an immunocom pt with an influenza A/B inf
pneumonitis
what is the treatment for influenza A/B inf in immunocompromised pt
oseltamivir OD 5days
what will human parvovirus cause in immunocomp pt
chronic anemia/aplastic anemia
