Fungal Infections Flashcards
2 types of fungi and examples
yeasts - candida, Cryptococcus
mould - aspergillus
what is the most common candida infection and what makes it easier to recognize
C. ablicans - has a germ tube
who is at an increased risk of candidiasis
VLBW infants on TPN after Ab therapy on ITU immunocomp
what is the treatment for candida infections
C. ablicans - fluconazole
other/empirical Tx - echinocandin
what should be suspected if insidious onset meningitis in immunocomp
Cryptococcus
what RF is Cryptococcus esp associated with
bird contact - esp pigeons
how is cryptococcus inf diagnosed
cryptococcal antigen in serum/CSf
india ink stain
how is croptococcus inf treated
3w amphotericin B + flucytosine
how will cryptococcus typically present
insidious onset meningitis in immunocomp (esp HIV)
how can aspergillosis present and what is the typical presentation
spectrum of diseases from allergy to invasion
typically - pneumonia in immunocompromised
how is aspergillosis treated
> 6w with ambisome/amphotericin B/variconazole
what typically causes superficial fungal infections
dermatophye -> tinea ___
how are dermatophye inf (tinea ___) diagnosed
skin scrapings
name 5 types/classes of antifungals and their targets
Azoles - vs cell memb Polyenes - vs cell memb Flucytosine - vs DNA synth Terbinafine - vs cell memb Echinocandins - vs cell wall
name 2 typical azoles
fluconazole, itraconazole
