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Pharmacology > Opioids > Flashcards

Opioids Flashcards

1
Q

Morphine

A

MOI: primarily mu, some kappa & delta agonist

uses: analgesic, anti-tussive

CI: respiratory dz

Adverse effects: dose-related CNS, CVS, respiratory depression, GI stasis, vomiting

cross BB: yes, intermediate

elimination: metabolized by liver

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2
Q

Why is half-life morphine longer in cats?

A

no glucuronidatio in cats

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3
Q

Naloxone

A

kappa, mu, delta antagonist

reversal for opioid tox

induce opioid withdrawal response

not controlled substance

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4
Q

Butorphenol

A

kappa agonist; mu agonist/antagonist

analgesi

AE: CNS excitement/sedation, GI stasis, vomiting

4-7x more potent analgesic compared to morphine-less respiratory depression

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5
Q

Fentanyl

A

mu agonist

analgesic

AE: dose-related CNS, CVS & respiratory depression, GI stasis, vomiting

BBB yes

liver

80-100x more POTENT than morphine

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6
Q

how do you treat opioid toxicity?

A

naloxone

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7
Q

What combination of drugs can you use to have neuroleptanalgesia?

A

dopamine antagonist (neuroleptic) + opioid

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8
Q
A
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Pharmacology (7 decks)

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