NSAIDS Flashcards
What are the three common side effects of NSAIDs?
gastropathy (irritation, nausea, bleeding, ulceration, erosions)
nephrotoxicity (acute renal failure)
idiosyncratic rxn (skin rxns, delayed healing)
Adverse effects of NSAIDs are ….. and ….. dependent?
dose and time
Which NSAID has a high VD?
flunixin (cattle)
tolfenamic acid (dog, calf, pig)
firocoxib (dog)
What are the common uses of NSAIDS?
analgesic, anti-inflammatory, anti-pyretic
what are the common adverse effects of NSAIDs?
adverse GI and renal effects
What species can I use carprofen in?
dogs & small animals
What are cats more suceptible to caprofen accumulation & side effects?
metabolized by liver via glucuronidation
What are general contraindications for NSAIDs?
patients w/ renal or hepatic insufficiency, bleeding ulcers
What drug interactions can occur w/ ketoprofen?
corticosteroids -worsen GI and renal AE
General time for NSAIDs to take action?
2 hours
Which NSAIDs are both COX-1 & 2 inhibitors?
carprofen
ketoprofen
flunixin
phenylbutazone
Name a COX-2 only inhibitor?
deracoxib
caprofen-has slightly more affinity for cox-2
What NSAID is approved for use in dogs & small animals?
carprofen
What two NSAIDs are specific for equines?
ketoprofen
phenylbutazone
Which NSAID can be used in many species?
deracoxib
