Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

neuro > opioids > Flashcards

opioids Flashcards

1
Q

opioid MOA

A

hyperpolarize nerve cells (open K+ channels)

inhibit NT release (block Ca2+ channels)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

opioid OD

A

pinpoint pupils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

endorphins

A

mu receptor

euphoria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

dynorphins

A

kappa receptor

dysphoria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

opioid SE

A 
sedation
respiratory depression
anti-tussive
nausea/vomiting
constipation
miosis
urinary retention
biliary spasm
pruritis
orthostatic hypotension
prolong labor
bronchoconstriction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

morphine absorption

A

first pass metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

morphine distribution

A

all body tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

morphine metabolism

A

conjugated in liver to glucronide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

morphine excretion

A

urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

morphine toxicity

A

pinpoint pupils
respiratory depression
coma

tx:
establish airway
opioid antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

morphine tolerance

A

downregulation of opioid receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

morphine abuse

A

euphoria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

morphine withdrawal

A

abstinence syndrome (CNS overactivity)

tx:
methadone
buprenorphine
clonidine
naltrexone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

morphone contraindications

A 
COPD
asthma
increased ICP
pregnant
liver/kidney disease
hypotension
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

meperidine vs morphine

A

less potent
shorter duration of action
less GI/biliary/uterine effect
anti-muscarinic effects (dilates pupil)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

meperidine toxicity

A

normeperidine causes serotonin syndrome

17
Q

fentanyl

A

highly potent
rapid onset
short duration

18
Q

fentanyl use

A

surgery
labor
cancer (transdermal patch, lozenge)

19
Q

fentanyl metabolism

A

CYP3A4

20
Q

fentanyl analogues

A

potent
rapid onset
short duration

sulfentanil
alfentanil
remifentanil

21
Q

methadonen use

A

chronic pain

opioid dependence

22
Q

oxycodone use

A

moderate/severe pain

opioid-tolerant pts (sustained release formulation)

23
Q

codeine metabolism

A

metabolized to morphine (CYP2D6)

24
Q

codeine use

A

antitussive

mild/moderate pain

25
Q

diphenoxylate use

A

use: diarrhea

low abuse potential

26
Q

pentazocine MOA

A

kappa agonist

weak mu antagonist

27
Q

pentazocine use

A

pain
pre-anesthetic
induce withdrawal

28
Q

pentazocine SE

A

psychomimetic effects
hallucination
ceiling effect

29
Q

buprenorphine

A

20x more potent than morphine

30
Q

buprenorphine MOA

A

partial mu agonist
kappa antagonist

long duration
precipitates withdrawal in morphine users

31
Q

buprenorphine SE

A

respiratory depression

32
Q

tramadol MOA

A

weak mu agonist

inhibit reuptake of NE and serotonin

33
Q

tramadol use

A

moderate pain

chronic neuropathic pain

34
Q

tramadol SE

A

respiratory depression

seizures

35
Q

naloxone

A

opioid antagonist

ineffective orally
first-pass metabolism to glucuronide

use: opioid overdoes

36
Q

naltrexone

A

opioid antagonist

high oral bioavailability
long duration of action
SE: CV

use: opioid dependence, alcoholism

37
Q

dextromethorphan

A 
NMDA antagonist (antitussive)
metabolized by CYP2D6

neuro (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions