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neuro > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

NSAIDs MOA

A

inhibit PG synthesis by blocking COX1 (gastric mucosa, platelet aggregation) and COX2 (inflammation, fever)

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2
Q

NSAIDs use

A

analgesic
anti-inflammatory
antipyretic
inhibit platelet aggregation

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3
Q

NSAID SE

A 
nausea/vomiting
GI ulceration
anti-coagulant
renal injury
pregnancy
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4
Q

aspirin

A

rapidly absorbed
widely distributed

anticoagulant

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5
Q

aspirin metabolism

A

plasma, liver

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6
Q

aspirin MOA

A

irreversibly inhibits COX1 and COX2
reduce TxA2 synthesis
reduce PGI synthesis

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7
Q

aspirin SE

A 
hypersensitivity
GI irritation/ulcers
liver toxicity
acute renal failure
Reye's syndrome (use acetaminophen)
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8
Q

aspirin OD

A 
salicylism:
dizziness
nausea/vomiting
tinnitus
hyperventilation
hyperthermia

tx: emesis/lavage, alkalinize urine

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9
Q

aspirin contraindications

A 
hypersensitivity
peptic ulcer
children
pregnancy
elderly
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10
Q

aspirin Rx interactions

A 
P450 enzymes
glucuronidation
alcohol
corticosteroids
NSAIDs
oral hypoglycemics
oral anticoagulants
anti-epileptics
systemic antacids
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11
Q

indomethACin use

A

acetic acid

RA
osteoarthritis
ankylosing spondylitis
acute gout

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12
Q

indomethACin SE

A

closure of patent ductus arteriosis
GI ulcer
severe frontal headache
hypersensitivity

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13
Q

sulindAC

A

acetic acid

prodrug

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14
Q

keterolAC use

A

acetic acid

moderate/severe pain

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15
Q

keterolAC SE

A

GI ulcer

don’t take for more than 5 days

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16
Q

diclofenAC use

A

acetic acid

RA osteoarthritis
solar keratoses
acute pain
pts with high risk ulcers

17
Q

ibuPROfen

A

propionic acid

well tolerated
low SE

18
Q

ibuPROfen use

A

mild/moderate pain

19
Q

ibuPROfen SE

A

GI irritation

20
Q

naPROxen

A

propionic acid

long halflife (14hr)
dose: 2x/day
21
Q

ketoPROfen

A

propionic acid

short halflife
dose: 3-4x/day

22
Q

fenoPROfen

A

pripionic acid

short halflife (2hr)
dose: 3-4x/day

SE: headaches 15%

contraindication: impaired renal function

23
Q

oxaPROzin

A

propionic acid

long halflife
dose: 1x/day

24
Q

meFENamic acid

A

fenamate

analgesic
use < 1 week

SE: diarrhea 25%

contraindication: impaired renal function

25
Q

mecloFENamate

A

fenamate

use: RA, osteoarthritis, mild/moderate pain

SE: GI irritation

26
Q

pirOXIcam

A

oxicam

long halflife (50hr)
dose: 1x/day

use: RA

SE: GI irritation

27
Q

melOXIcam

A

oxicam

COX2 inhibitor

long halflife (50hr)
dose: 1x/day

use: RA, osteoarthritis, mild/moderate pain

SE: less GI irritation, platelet aggregation

28
Q

nabumetone

A

prodrug (CYP1A2)

long halflife (27hr)
dose: 1x/day

use: RA

SE: Gi irritation, renal toxicity

29
Q

celecoxib

A

COX2 inhibitor

metabolized by CYP2C9
halflife (11hr)
dose: 2x/day

use: osteoarthritis, RA, dysmenorrhea, reduce risk of colon cancer

doesn’t inhibit platelet aggregation
fewer GI effects

SE: prothrombotic

contraindication: impaired renal function

30
Q

acetaminophen

A

well absorbed
conjugated to glucuronide & sulfate by P450

toxicity: high doses

no GI irritation

31
Q

acetaminophen use

A 
ASA contraindication
no need for anti-inflammatory
bleeding disorders
peptic ulcer
children
32
Q

acetaminophen SE

A

hypersensitivity

hepatotoxicity (tx: N-acetylcysteine within 8-10hr)

33
Q

acetaminophen contraindications

A

hypersensitivity
impaired liver function
alcoholism

34
Q

ergot alkaloids

A

vasoconstriction

SE: nausea/vomiting, leg weakness, muscle pain

toxicity: ergot poisoning

35
Q

triptans

A

anti-emetic

MOA: stimulate 5HT1B/D receptors

SE: CNS effects, serotonin syndrome

36
Q

beta-blockers

A

MOA: vasoconstriction, decreased sympathetics

SE: coronary vasospasms

37
Q

Ca2+ channel blockers

A

MOA: reduce Ca2+ influx, reduce vasospasms

38
Q

anticonvulsants

A

ion channel blockers

39
Q

angiotensin II receptor blocker

A

MOA: blocks production of angiotensin II

use: high BP

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