adrenergics Flashcards
EPI - MOA
bronchodilator (b2)
EPI - use
anaphylaxis
shock: vasodilate
local anesthetic: vasoconstrict (a1)
EPI - SE
high BP
high HR
hyperthyroidism: upregulate b1
NE - MOA
vasoconstriction (a1)
NE - use
shock
hypotension
decrease renal bloodflow
NE - SE
hyperthyroidism: upregulate b1
DA - dosing/MOA
low: d1 - increase renal bloodflow
med: d1 & b1 - increase BP, CO
high: d1, b1, a1/a2 - vasoconstriction
DA - use
shock
congestive heart failure
DA - SE
arrhythmias
nausea, vomiting (d1)
indirect sympathomimetics - MOA
induce NT release
block NT reuptake
amphetamine - use
ADHD, narcolepsy
cocaine - MOA
block Na+ channels (prevents AP)
cocaine - use
topical anesthesia
tyramine - SE
contraindicated if taking MAO inhibitor - isn’t broken down, replaces NE in nerve terminals, causes fatal HTN
mixed sympathomimetics: ephedrine
weak a1, b agonist
release NE
decongestant
direct a1 agonist
vasoconstriction
constrict sphincter
Milodrine
a1 agonist
prodrug
use: orthostatic hypotension, incontinence
Metaraminol
a1 agonist
use:
shock
hypotension
Phenylephrine
selective a1 agonist
use:
nasal decongestant
mydriasis
hypotension
Oxymetazoline (eye drops)
a1 agonist
a2 partial agonist
use:
vasoconstriction of eye vessels
direct a2 agonist: clonidine
inhibits sympathetic outflow
use:
HTN
drug withdrawal
ADHD
SE:
abrupt withdrawal causes tachychardia/arrhythmias
alpha antagonist
vasodilation
sphincter relaxation
phentolamine
competitive alpha antagonist
MOA:
vasodilation
block inhibitory a2 receptors
use:
short-term control of HTN
SE:
hypotension
tachycardia
nasal congestion
phenoxybenzamine
irreversible alpha antagonist
use:
pleochromocytoma (adrenal tumor secretes too much NE)
SE:
hypotension
tachycardia
nasal congestion
prazosin
selective a1 antagonist
use: HTN
SE: hypotension
direct beta agonist
cardiac stimulant
isoproterenol
b1 agonist - increase HR
b2 agonist - vasodilate
dobutamine
b1/b2 agonist - increase HR, vasodilate
a1 agonist - vasoconstrict
direct b2 agonist
b2 - think lung
inhibit release of inflammatory mediators
use: asthma
SE:
CV stimulation
tremors
albuterol
direct b2 agonist
use: asthma, delay labor
terbutaline
direct b2 agonist
oral, IV
salmeterol
direct b2 agonist
inhaled, long-acting
direct b3 agonist: mirabegron
MOA: relax detrussor M
use: overactive bladder
beta antagonists
“lol”
decrease HR, contractility, CO, O2 demand
risk: asthma, COPD, diabetes
discontinue slowly
propanolol
b1, b2 antagonist
membrane stabilizing
use:
arrhythmias, MI, HTN, angina, hyperthyroidism, anxiety
SE:
bradycardia, depression, insomnia
nadolol
b1, b2 antagonist
non-membrane stabilizing
long acting
carvedilol
b1, b2 antagonist
a1 antagonist - decrease BP
use: CHF
labetalol
b1, b2 antagonist
a1 antagonist - decrease BP
intrinsic sympathomimetic activity
use: CHF
timolol
b1, b2 antagonist
use: topical, glaucoma
carteolol
b1, b2 antagonist
use: topical, glaucoma
b1 antagonist
decrease HR, contractility, CO
atenolol
b1 antagonist
use:
HTN
angina
MI
risk: asthma, diabetes
doesn’t cross BBB
metoprolol
b1 antagonist
use:
HTN
angina
MI
crosses BBB
