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neuro > adrenergics > Flashcards

adrenergics Flashcards

1
Q

EPI - MOA

A

bronchodilator (b2)

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2
Q

EPI - use

A

anaphylaxis
shock: vasodilate
local anesthetic: vasoconstrict (a1)

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3
Q

EPI - SE

A

high BP
high HR
hyperthyroidism: upregulate b1

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4
Q

NE - MOA

A

vasoconstriction (a1)

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5
Q

NE - use

A

shock
hypotension
decrease renal bloodflow

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6
Q

NE - SE

A

hyperthyroidism: upregulate b1

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7
Q

DA - dosing/MOA

A

low: d1 - increase renal bloodflow
med: d1 & b1 - increase BP, CO
high: d1, b1, a1/a2 - vasoconstriction

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8
Q

DA - use

A

shock

congestive heart failure

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9
Q

DA - SE

A

arrhythmias

nausea, vomiting (d1)

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10
Q

indirect sympathomimetics - MOA

A

induce NT release

block NT reuptake

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11
Q

amphetamine - use

A

ADHD, narcolepsy

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12
Q

cocaine - MOA

A

block Na+ channels (prevents AP)

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13
Q

cocaine - use

A

topical anesthesia

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14
Q

tyramine - SE

A

contraindicated if taking MAO inhibitor - isn’t broken down, replaces NE in nerve terminals, causes fatal HTN

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15
Q

mixed sympathomimetics: ephedrine

A

weak a1, b agonist
release NE
decongestant

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16
Q

direct a1 agonist

A

vasoconstriction

constrict sphincter

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17
Q

Milodrine

A

a1 agonist

prodrug

use: orthostatic hypotension, incontinence

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18
Q

Metaraminol

A

a1 agonist

use:
shock
hypotension

19
Q

Phenylephrine

A

selective a1 agonist

use:
nasal decongestant
mydriasis
hypotension

20
Q

Oxymetazoline (eye drops)

A

a1 agonist
a2 partial agonist

use:
vasoconstriction of eye vessels

21
Q

direct a2 agonist: clonidine

A

inhibits sympathetic outflow

use:
HTN
drug withdrawal
ADHD

SE:
abrupt withdrawal causes tachychardia/arrhythmias

22
Q

alpha antagonist

A

vasodilation

sphincter relaxation

23
Q

phentolamine

A

competitive alpha antagonist

MOA:
vasodilation
block inhibitory a2 receptors

use:
short-term control of HTN

SE:
hypotension
tachycardia
nasal congestion

24
Q

phenoxybenzamine

A

irreversible alpha antagonist

use:
pleochromocytoma (adrenal tumor secretes too much NE)

SE:
hypotension
tachycardia
nasal congestion

25
Q

prazosin

A

selective a1 antagonist

use: HTN

SE: hypotension

26
Q

direct beta agonist

A

cardiac stimulant

27
Q

isoproterenol

A

b1 agonist - increase HR

b2 agonist - vasodilate

28
Q

dobutamine

A

b1/b2 agonist - increase HR, vasodilate

a1 agonist - vasoconstrict

29
Q

direct b2 agonist

A

b2 - think lung

inhibit release of inflammatory mediators

use: asthma

SE:
CV stimulation
tremors

30
Q

albuterol

A

direct b2 agonist

use: asthma, delay labor

31
Q

terbutaline

A

direct b2 agonist

oral, IV

32
Q

salmeterol

A

direct b2 agonist

inhaled, long-acting

33
Q

direct b3 agonist: mirabegron

A

MOA: relax detrussor M

use: overactive bladder

34
Q

beta antagonists

A

“lol”

decrease HR, contractility, CO, O2 demand

risk: asthma, COPD, diabetes

discontinue slowly

35
Q

propanolol

A

b1, b2 antagonist

membrane stabilizing

use:
arrhythmias, MI, HTN, angina, hyperthyroidism, anxiety

SE:
bradycardia, depression, insomnia

36
Q

nadolol

A

b1, b2 antagonist

non-membrane stabilizing

long acting

37
Q

carvedilol

A

b1, b2 antagonist
a1 antagonist - decrease BP

use: CHF

38
Q

labetalol

A

b1, b2 antagonist
a1 antagonist - decrease BP

intrinsic sympathomimetic activity

use: CHF

39
Q

timolol

A

b1, b2 antagonist

use: topical, glaucoma

40
Q

carteolol

A

b1, b2 antagonist

use: topical, glaucoma

41
Q

b1 antagonist

A

decrease HR, contractility, CO

42
Q

atenolol

A

b1 antagonist

use:
HTN
angina
MI

risk: asthma, diabetes

doesn’t cross BBB

43
Q

metoprolol

A

b1 antagonist

use:
HTN
angina
MI

crosses BBB

neuro (12 decks)

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