Opioid Toxicity

Question 1

Opioid Toxicity
Indications

Answer 1

Altered LOC
AND
Respiratory Depression
AND
Inability to adequately ventilate OR persistent need to assist ventilations
AND
Suspected opioid overdose

Question 2

Naloxone
Conditions
Age?
LOA?
RR?

Answer 2

Age: ≥ 24 hours
LOA: Altered
RR: < 10 breaths/min

Question 3

Naloxone
Route - IV / IO
Dose?
Max. Single Dose?
Dosing interval?
Max # of Doses?

Answer 3

Dose: up to 0.4mg
Max. Single Dose: 0.4mg
Dosing interval: 5min
Max # of Doses: 3

gradual titration to desired clinical effect

Question 4

Naloxone
Route - IM
Dose?
Max. Single Dose?
Dosing interval?
Max # of Doses?

Answer 4

Dose: 0.4mg
Max. Single Dose: 0.4mg
Dosing interval: 5min
Max # of Doses: 3

Question 5

Naloxone
Route - IN
Dose?
Max. Single Dose?
Dosing interval?
Max # of Doses?

Answer 5

Dose: 2-4mg
Max. Single Dose: 2-4mg
Dosing interval: 5min
Max # of Doses: 3

Question 6

Naloxone
Route - SC
Dose?
Max. Single Dose?
Dosing interval?
Max # of Doses?

Answer 6

Dose: 0.8mg
Max. Single Dose: 0.8mg
Dosing interval: 5min
Max # of Doses: 3