Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc

Question 1

What type of drug is Fentanyl?

Answer 1

Opioid Agonist, phenylpiperidine

Question 2

What type of drug is Meperidine (Demerol)?

Answer 2

It is a opioid analgesic. A phenylpiperdine

Question 3

What is the half-life for Morphine?

Answer 3

2-3 hr

Question 4

What type of Drug is Sufentanil?

Answer 4

Opioid Agonist, phenylpiperidine

Question 5

What is the half-life of Meperidine?

Answer 5

3-5 hr

Question 7

What is the narcotic equivalent for Morphine?

Answer 7

1 , it is what we compare everything to.

Question 8

What is the Narcotic equivalent for Meperidine?

Answer 8

1/10, or 0.1

Question 9

What are the side-effects/contraindications for Fentanyl?

Answer 9

Asthenia, confusion, dry mouth, constipation, N/V

Question 10

What type of drug is Morphine?

Answer 10

Opioid Agonist, phenanthrene

Question 11

What type of drug is Alfentanil?

Answer 11

Opioid Agonist, phenylpiperidine

Question 12

What is the dose of Meperidine?

Answer 12

2.5-5 mg/kg

Question 12

What is the volume of distribution for Morphine?

Answer 12

3-5 L/Kg

Question 14

What is the half-life of Fentanyl?

Answer 14

1-5 hr
CS (context sensitive):
4 hours

Question 15

What is the MOA of Meperidine (Demerol) and how is it metabolized and eliminated?

Answer 15

Opioid receptor agonist
Metabolism: Liver
Elimination: Renal

Question 16

What is the MOA, metabolism, and excretion of Sufentanil?

Answer 16

Opioid receptor agonist
Metabolism: Liver
Elimination: Renal, biliary

Question 17

What are the side effects/contraindications of Meperidine?

Answer 17

Histamine release, N/V, constipation, hypotension, anti-shivering-kappa

Question 17

What is the induction dose of Fentanyl?

Answer 17

Induction: 1-2 mcg/kg then 1-3 mcg/kg/hr continuous

Question 18

What are the side effects/contraindications of Sufentanil?

Answer 18

Asthenia, confusion, constipation, N/V, dry mouth

Question 20

What are the loading and maintenance doses of Alfentanil?

Answer 20

Loading: 8-100 mcg/kg
Maintenance: 0.5-3 mcg/kg/min

Question 21

What is the induction dose for Sufentanil?

Answer 21

Induction: 1-2 mcg/kg then 10-50 mcg prn; Anesthesia: 8-30 mcg then 25-30 mcg prn

Question 22

What is the MOA, metabolism and excretion of Fentanyl?

Answer 22

Opioid receptor agonist

Metabolism: Lung and Liver (dependent on blood flow)

Question 23

Naloxone: MOA, dose, ½ life, route of metabolism and elimination

Answer 23

Opioid antagonist
Competitive antagonism of opiate receptors
Metabolism: Liver
Elimination: Renal
Dose (incremental) 0.4 mg (10 mcg/kg) may repeat q2-3 min
1/2 life: 60-90 min
Side effects/contraindications: Withdrawal reactions (N/V, tachycardia, sweating, HTN, tremors), cardiac arrest, VF, pulm edema

Question 24

What are the side effects/contraindications for Morphine?

Answer 24

Histamine release, pruritis, vomiting, urinary retention, constipation, HA

Question 25

What is Fentanyl’s Vd?

Answer 25

2-8

Question 25

What is the half-life of Sufentanil?

Answer 25

3 hr CS (context sensitive): 30 min

Question 26

What is the half-life of Alfentanil?

Answer 26

1-2 hr CS: 60 min.

Question 27

What is the narcotic equivalent of Sufentanil?

Answer 27

500-1000

Question 30

Nalbuphine (Nubain): MOA?

Answer 30

Opioid Agonist/ antagonist | Opiate receptor agonist in CNS

Question 31

What is the MOA, metabolism, and excretion of Alfentanil?

Answer 31

Opioid receptor agonist Metabolism: Liver Excretion: Renal

Question 32

What is Meperidine's volume of distribution?

Answer 32

3-5 L/Kg

Question 32

What is the narcotic equivalent for Fentanyl?

Answer 32

100

Question 33

What is the Vd of Sufentanil?

Answer 33

2.5-3 L/Kg

Question 33

What is the narcotic equivalent of Alfentanil?

Answer 33

10-20

Question 34

Remifentanil: Class, MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Answer 34

``` Opioid Agonist, phenylpiperidine Opioid receptor agonist Metabolism: Non-specific esterases Excretion: Metabolites are renally excreted Loading: 1 mcg/kg Intra-op: 0.5-3mcg/kg/min Narc equivalent 100 Vd: 0.3-0.4L/Kg Half life: <10min CS: 4 min. Side effects: Asthenia, confusion, constipation, N/V, dry mouth ```

Question 35

What is Morphine's MOA, metabolism, and excretion?

Answer 35

Opioid receptor agonist Metabolism: Liver Excretion: Renal

Question 35

Butorphanol (Stadol): Class and MOA?

Answer 35

Opioid Agonist/ antagonist | Opiate receptor agonist in CNS

Question 36

What are the side effects/contraindications of Alfentanil?

Answer 36

Asthenia, confusion, constipation, N/V, dry mouth