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Pharm 512 Drugs > Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc > Flashcards

Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc Flashcards

1
Q

What type of drug is Fentanyl?

A

Opioid Agonist, phenylpiperidine

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2
Q

What type of drug is Meperidine (Demerol)?

A

It is a opioid analgesic. A phenylpiperdine

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3
Q

What is the half-life for Morphine?

A

2-3 hr

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4
Q

What type of Drug is Sufentanil?

A

Opioid Agonist, phenylpiperidine

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5
Q

What is the half-life of Meperidine?

A

3-5 hr

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7
Q

What is the narcotic equivalent for Morphine?

A

1 , it is what we compare everything to.

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8
Q

What is the Narcotic equivalent for Meperidine?

A

1/10, or 0.1

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9
Q

What are the side-effects/contraindications for Fentanyl?

A

Asthenia, confusion, dry mouth, constipation, N/V

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10
Q

What type of drug is Morphine?

A

Opioid Agonist, phenanthrene

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11
Q

What type of drug is Alfentanil?

A

Opioid Agonist, phenylpiperidine

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12
Q

What is the dose of Meperidine?

A

2.5-5 mg/kg

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12
Q

What is the volume of distribution for Morphine?

A

3-5 L/Kg

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14
Q

What is the half-life of Fentanyl?

A

1-5 hr
CS (context sensitive):
4 hours

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15
Q

What is the MOA of Meperidine (Demerol) and how is it metabolized and eliminated?

A

Opioid receptor agonist
Metabolism: Liver
Elimination: Renal

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16
Q

What is the MOA, metabolism, and excretion of Sufentanil?

A

Opioid receptor agonist
Metabolism: Liver
Elimination: Renal, biliary

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17
Q

What are the side effects/contraindications of Meperidine?

A

Histamine release, N/V, constipation, hypotension, anti-shivering-kappa

17
Q

What is the induction dose of Fentanyl?

A

Induction: 1-2 mcg/kg then 1-3 mcg/kg/hr continuous

18
Q

What are the side effects/contraindications of Sufentanil?

A

Asthenia, confusion, constipation, N/V, dry mouth

20
Q

What are the loading and maintenance doses of Alfentanil?

A

Loading: 8-100 mcg/kg
Maintenance: 0.5-3 mcg/kg/min

21
Q

What is the induction dose for Sufentanil?

A

Induction: 1-2 mcg/kg then 10-50 mcg prn; Anesthesia: 8-30 mcg then 25-30 mcg prn

22
Q

What is the MOA, metabolism and excretion of Fentanyl?

A

Opioid receptor agonist

Metabolism: Lung and Liver (dependent on blood flow)

23
Q

Naloxone: MOA, dose, ½ life, route of metabolism and elimination

A

Opioid antagonist
Competitive antagonism of opiate receptors
Metabolism: Liver
Elimination: Renal
Dose (incremental) 0.4 mg (10 mcg/kg) may repeat q2-3 min
1/2 life: 60-90 min
Side effects/contraindications: Withdrawal reactions (N/V, tachycardia, sweating, HTN, tremors), cardiac arrest, VF, pulm edema

24
Q

What are the side effects/contraindications for Morphine?

A

Histamine release, pruritis, vomiting, urinary retention, constipation, HA

25
Q

What is Fentanyl’s Vd?

A

2-8

25
Q

What is the half-life of Sufentanil?

A

3 hr
CS (context sensitive):
30 min

26
Q

What is the half-life of Alfentanil?

A

1-2 hr
CS:
60 min.

27
Q

What is the narcotic equivalent of Sufentanil?

A

500-1000

30
Q

Nalbuphine (Nubain): MOA?

A

Opioid Agonist/ antagonist

Opiate receptor agonist in CNS

31
Q

What is the MOA, metabolism, and excretion of Alfentanil?

A

Opioid receptor agonist
Metabolism: Liver
Excretion: Renal

32
Q

What is Meperidine’s volume of distribution?

A

3-5 L/Kg

32
Q

What is the narcotic equivalent for Fentanyl?

A

100

33
Q

What is the Vd of Sufentanil?

A

2.5-3 L/Kg

33
Q

What is the narcotic equivalent of Alfentanil?

A

10-20

34
Q

Remifentanil: Class, MOA, induction dose, Vd, 1/2 life, metabolism, excretion

A 
Opioid Agonist, phenylpiperidine
Opioid receptor agonist
Metabolism: Non-specific esterases
Excretion: Metabolites are renally excreted
Loading: 1 mcg/kg
Intra-op: 0.5-3mcg/kg/min
Narc equivalent 100
Vd: 0.3-0.4L/Kg
Half life: <10min CS: 4 min.
Side effects: Asthenia, confusion, constipation, N/V, dry mouth
35
Q

What is Morphine’s MOA, metabolism, and excretion?

A

Opioid receptor agonist
Metabolism: Liver
Excretion: Renal

35
Q

Butorphanol (Stadol): Class and MOA?

A

Opioid Agonist/ antagonist

Opiate receptor agonist in CNS

36
Q

What are the side effects/contraindications of Alfentanil?

A

Asthenia, confusion, constipation, N/V, dry mouth

Pharm 512 Drugs (16 decks)

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