Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc Flashcards
What type of drug is Fentanyl?
Opioid Agonist, phenylpiperidine
What type of drug is Meperidine (Demerol)?
It is a opioid analgesic. A phenylpiperdine
What is the half-life for Morphine?
2-3 hr
What type of Drug is Sufentanil?
Opioid Agonist, phenylpiperidine
What is the half-life of Meperidine?
3-5 hr
What is the narcotic equivalent for Morphine?
1 , it is what we compare everything to.
What is the Narcotic equivalent for Meperidine?
1/10, or 0.1
What are the side-effects/contraindications for Fentanyl?
Asthenia, confusion, dry mouth, constipation, N/V
What type of drug is Morphine?
Opioid Agonist, phenanthrene
What type of drug is Alfentanil?
Opioid Agonist, phenylpiperidine
What is the dose of Meperidine?
2.5-5 mg/kg
What is the volume of distribution for Morphine?
3-5 L/Kg
What is the half-life of Fentanyl?
1-5 hr
CS (context sensitive):
4 hours
What is the MOA of Meperidine (Demerol) and how is it metabolized and eliminated?
Opioid receptor agonist
Metabolism: Liver
Elimination: Renal
What is the MOA, metabolism, and excretion of Sufentanil?
Opioid receptor agonist
Metabolism: Liver
Elimination: Renal, biliary
What are the side effects/contraindications of Meperidine?
Histamine release, N/V, constipation, hypotension, anti-shivering-kappa
What is the induction dose of Fentanyl?
Induction: 1-2 mcg/kg then 1-3 mcg/kg/hr continuous
What are the side effects/contraindications of Sufentanil?
Asthenia, confusion, constipation, N/V, dry mouth
What are the loading and maintenance doses of Alfentanil?
Loading: 8-100 mcg/kg
Maintenance: 0.5-3 mcg/kg/min
What is the induction dose for Sufentanil?
Induction: 1-2 mcg/kg then 10-50 mcg prn; Anesthesia: 8-30 mcg then 25-30 mcg prn
What is the MOA, metabolism and excretion of Fentanyl?
Opioid receptor agonist
Metabolism: Lung and Liver (dependent on blood flow)
Naloxone: MOA, dose, ½ life, route of metabolism and elimination
Opioid antagonist
Competitive antagonism of opiate receptors
Metabolism: Liver
Elimination: Renal
Dose (incremental) 0.4 mg (10 mcg/kg) may repeat q2-3 min
1/2 life: 60-90 min
Side effects/contraindications: Withdrawal reactions (N/V, tachycardia, sweating, HTN, tremors), cardiac arrest, VF, pulm edema
What are the side effects/contraindications for Morphine?
Histamine release, pruritis, vomiting, urinary retention, constipation, HA
What is Fentanyl’s Vd?
2-8
What is the half-life of Sufentanil?
3 hr
CS (context sensitive):
30 min
What is the half-life of Alfentanil?
1-2 hr
CS:
60 min.
What is the narcotic equivalent of Sufentanil?
500-1000
Nalbuphine (Nubain): MOA?
Opioid Agonist/ antagonist
Opiate receptor agonist in CNS
What is the MOA, metabolism, and excretion of Alfentanil?
Opioid receptor agonist
Metabolism: Liver
Excretion: Renal
What is Meperidine’s volume of distribution?
3-5 L/Kg
What is the narcotic equivalent for Fentanyl?
100
What is the Vd of Sufentanil?
2.5-3 L/Kg
What is the narcotic equivalent of Alfentanil?
10-20
Remifentanil: Class, MOA, induction dose, Vd, 1/2 life, metabolism, excretion
Opioid Agonist, phenylpiperidine Opioid receptor agonist Metabolism: Non-specific esterases Excretion: Metabolites are renally excreted Loading: 1 mcg/kg Intra-op: 0.5-3mcg/kg/min Narc equivalent 100 Vd: 0.3-0.4L/Kg Half life: <10min CS: 4 min. Side effects: Asthenia, confusion, constipation, N/V, dry mouth
What is Morphine’s MOA, metabolism, and excretion?
Opioid receptor agonist
Metabolism: Liver
Excretion: Renal
Butorphanol (Stadol): Class and MOA?
Opioid Agonist/ antagonist
Opiate receptor agonist in CNS
What are the side effects/contraindications of Alfentanil?
Asthenia, confusion, constipation, N/V, dry mouth
