Antiemetics Flashcards
1
Q
Ondansetron (Zofran): MOA and dose?
A
MOA:
Selectively blocks serotonin 5-HT3 receptors peripherally (Abd vagal afferents) & centrally (CTZ)
Periop: IV 4mg (on emergence)
Dose:
Postop: IV/PO 4mg
2
Q
Metoclopramide (Reglan)
A
MOA:
Dopamine 2 receptor antagonist, Blocks DA receptors at the CTZ; stimulates upper GI motility and ↑ gastric emptying
Dose:
Preop: 10-20 mg IV over 3-5min to decrease gastric fluid
Postop: 10mg at end of procedure for NV
3
Q
Promethazine (Phenergan): MOA and dose?
A
MOA:
H1 receptor antagonist, anticholinergic, a antagonist, dopaminergic antagonist (CTZ)
Dose:
12.5 - 25 mg
