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Pharm 512 Drugs > Non-Opioid Analgesic doses > Flashcards

Non-Opioid Analgesic doses Flashcards

1
Q

What is the dose for Tylenol?

A

650-1000 mg IV q 4-6hr

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2
Q

What is Tylenols MOA?

A

Unclear, possibly COX-2 inhibitor within CNS, inhibits prostaglandin synthesis

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3
Q

What are the anesthetic indications for Tylenol?

A

Anesthesia concerns: Monitor BP. Do not exceed max daily dose (<2g/day) d/t hepatic enzyme induction and impaired glucuronidation

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4
Q

What is the half-life of Tylenol?

A

1-3 hours

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5
Q

What are side effects/contraindications of Tylenol?

A

N/V, HA, insomnia; Hepatotoxic

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6
Q

What is Ibuprofens MOA?

A

COX-1 & COX-2 inhibitor; antipyretic, anti-inflammatory, & analgesic

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7
Q

What are the anesthetic concerns for Ibuprofen?

A

Anesthesia concerns: Increased concern w/ pts at risk for renal dysfunction, altered platelet fxn, and GI irritation. Monitor BP. May increase fluid accumulation/edema in CHF pts.

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8
Q

What is the dose for Ibuprofen?

A

400-800 mg IV q 6hr

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9
Q

What are side effects/contraindications of Ibuprofen?

A

Dizziness, epigastric pain, rash, tinnitus, renal dysfunction

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10
Q

What is the half-life of Ibuprofen?

A

2.2-2.4 hr

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11
Q

What is Ketorolac’s MOA?

A

COX-1 & COX-2 inhibitor

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12
Q

What is Ketorolac’s dose?

A

30 mg IM
15 mg or 30 mg IV Q6H
(Not to exceed 120mg in 24hrs)

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13
Q

What are the anesthetic concerns for Ketorolac?

A

Anesthesia concerns: PDA closure when given peripartum, renal toxicity in pts with renal diseases, bleeding risk.

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14
Q

What is the half-life of Ketorolac?

A

2-6 hr

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15
Q

What are the side-effects/contraindications of Ketorolac?

A

Dyspepsia, HA, GI pain, nausea, somnolence, renal dysfxn

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16
Q

What is the MOA of Celebrex?

A

COX-2 inhibitor

17
Q

What is the dose of Celebrex?

A

200 mg PO daily or divided BID

18
Q

What are the anesthetic concerns for Celebrex?

A

Anesthesia concerns: Does NOT inhibit platelets or prolong bleeding time.

19
Q

What is the half-life of Celebrex?

A

11 hr

20
Q

What are the side-effects/contraindications of Celebrex?

A

HTN, HA, fever, dyspepsia, URI, ↑risk of MI/CVA, fluid retention, renal injury; avoid in sulfa/ASA allergies

21
Q

What is the MOA for ASA?

A

Irreversible Non-selective COX inhibitor

22
Q

What is the dose for ASA?

A

81 mg for anti-thrombotic treatment

23
Q

What are the indications for ASA?

A

Decrease fever, Anti-platelet effects

Pharm 512 Drugs (16 decks)

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