Benzos, and Barbiturates Dosing, MOA, etc.

Question 1

Thiopental: MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Answer 1

MOA: GABA-mimetic; anti-epileptic
ID:4 mg/kg
Vd: 1.7-2.5 L
1/2 life: 3-8 hr
Metabolism: Liver (enzyme inducers)
Excretion: Kidney

Question 2

Methohexital: MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Answer 2

MOA: Alters sensory cortex, cerebellar, & motor activities; faster than thiopental
ID: 1-2mg/kg
Vd: 1.9-2.2 L
1/2 life: 1.5-5 hrs
Metab: liver
Excretion: kidney

Question 3

Midazolam: MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Answer 3

MOA: Potentiates GABA through allosteric binding at benzo site on receptor
ID: 0.1-0.4 mg/kg
Vd: 0.5-1.5 L (1L)
1/2 Life: 2-6 hrs.
Metab: liver
Excretion: Kidney

Question 4

Diazepam: MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Answer 4

MOA: Potentiates GABA through allosteric binding at benzo site on receptor
ID: 0.3-0.6 mg/kg
Vd: 1-2 L
1/2 life: 20-50 hrs.
Metab: Liver
Excretion: kidney

Question 5

Lorazepam: MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Answer 5

MOA: Potentiates GABA through allosteric binding at benzo site on receptor
ID: none
Vd. 1-3
1/2 life: 10-20 hrs
Metab: liver
Excretion: kidney

Question 6

Flumazenil: MOA, indication, 1/2 life

Answer 6

MOA: competitive benzo antagonist- reversal agent
Indicated: benzo overdose
1/2 life 30-60 min