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Neuro Pharmacology > Opioid Analgesics > Flashcards

Opioid Analgesics Flashcards

1
Q

morphine

A

strong opioid agonist

Rx: severe pain

MOA: mu receptor activation

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2
Q

fentanyl

A

strong opioid agonist

Rx: severe pain

MOA: mu receptor activation

exists as transdermal patch (72 hours)

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3
Q

meperidine

A

strong opioid agonist

Rx: severe pain

MOA: mu receptor activation

MAO Inhibitors Contraindicated!

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4
Q

methadone

A

strong opioid agonist

Rx: severe pain

MOA: mu receptor activation

Rx: Tx of opioid addiction (milder withdrawal symptoms)

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5
Q

sufentanil

A

strong opioid agonist

Rx: severe pain

MOA: mu receptor activation

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6
Q

heroin

A

strong opioid agonist

Rx: severe pain

MOA: mu receptor activation

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7
Q

codeine

A

moderate opioid agonist

Rx: cough suppressant; moderate pain

produces less euphoria
lower abuse potential
rarely leads to physical dependence
can produce sedation

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8
Q

oxycodone

A

moderate opioid agonist

Rx: moderate pain

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9
Q

hydrocodone

A

moderate opioid agonist

Rx: moderate pain

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10
Q

dextromethorphan

A

Other Opioid Agonist

cough suppressant

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11
Q

diphenoxylate

A

Other Opioid Agonist

Antidiarrheal Agent

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12
Q

loperamide

A

Other Opioid Agonist

Antidiarrheal Agent

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13
Q

tramadol

A

Other Opioid Agonist

Mu agonist + 5HT/NE uptake inhibitor

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14
Q

buprenorphine

A

Mixed Opioid agonist-antagonist

Partial activator of mu receptor; blocks kappa receptor

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15
Q

butorphanol

A

Mixed Opioid agonist-antagonist

Activate kappa receptor; block or partially activate mu receptor

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16
Q

nalbuphine

A

Mixed Opioid agonist-antagonist

Activate kappa receptor; block or partially activate mu receptor

17
Q

pentazocine

A

Mixed Opioid agonist-antagonist

Activate kappa receptor; block or partially activate mu receptor

18
Q

hydromorphone

A

strong opioid agonist

7-10x more potent analgesic than morphine

19
Q

Naloxone

A

Opioid Antagonist

Rx: opioid overdose

IV use produces CNS/respiratory depression in 30 sec.

20
Q

Naltrexone

A

Opioid Antagonist

Rx: maintenance drug for addicts in Tx programs

21
Q

Nalmefene

A

Opioid Antagonist

22
Q

oxymorphone

A

strong opioid agonist

Neuro Pharmacology (11 decks)

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