Antidepressants Flashcards
Phenelzine
Non-selective MAO-A and MAO-B Inhibitor (Irreversible)
MAO-A: targets tyramine, NE, 5HT, DA
MAO-B: targets DA
Tranylcypromine
Non-selective MAO-A and MAO-B Inhibitor (Irreversible)
MAO-A: targets tyramine, NE, 5HT, DA
MAO-B: targets DA
Selegiline
MAO-B Inhibitor (Irreversible) at low dose
Non-selective MAO-I at high dose
Rx: low dose – Parkinson’s, high dose – antidepressant (patch to prevent 1st pass effect)
MAO-A: targets tyramine, NE, 5HT, DA
MAO-B: targets DA
Imapramide
TCA
MOA: block re-uptake of 5HT and NE by inhibition of SERT and NET
Rx: enuresis
SE: lethal cardiac arrhythmias
Desipramide
TCA
MOA: block re-uptake of 5HT and NE by inhibition of SERT and NET
Rx: Neuorpathic pain
SE: lethal cardiac arrhythmias
Amitriptyline
TCA
MOA: block re-uptake of 5HT and NE by inhibition of SERT and NET
Sedative effects
SE: lethal cardiac arrhythmias
TCA overdose
Convulsions, Coma, Cardiac arrhthmias
Can be FATAL.
Fluoxetine
SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal
SE: GI disturbances, ↓ sexual function, headaches, sleep changes
Rx: major depression, GAD, PTSD, OCD
Sertraline
SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal
SE: GI disturbances, ↓ sexual function, headaches, sleep changes
Rx: major depression, GAD, PTSD, OCD
Paroxetine
SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal
SE: GI disturbances, ↓ sexual function, headaches, sleep changes
Rx: major depression, GAD, PTSD, OCD
Citalopram
SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal
SE: GI disturbances, ↓ sexual function, headaches, sleep changes
Rx: major depression, GAD, PTSD, OCD
Escitalopram
SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal
SE: GI disturbances, ↓ sexual function, headaches, sleep changes
Rx: major depression, GAD, PTSD, OCD
Fluvoxamine
SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal
SE: GI disturbances, ↓ sexual function, headaches, sleep changes
Rx: major depression, GAD, PTSD, OCD
Venlafaxine
SNRI
MOA: Inhibit SERT and NET transporters
Rx: severe depression
Duloxetine
SNRI
MOA: Inhibit SERT and NET transporters
Rx: chronic pain
Trazodone
5-HT2 Antagonist
MOA: Inhibition of 5HT-2A receptors
Rx: insomnia
SE: blocks H1 receptor (sedation), cases priapism (prolonged, painful erection)
Bupropion
Other Antidepressant
MOA: Blocks DA and NE reuptake
Rx: Smoking Cessation
Mirtazapine
Other Antidepressant
MOA: Blocks presynaptic alpha-2 adrenergic autoreceptors, ↑ synaptic release of 5HT and NE; antagonist of 5HT3 and 5HT2 receptors (anti-emetic); blocks H1 (sedation, weight gain)
Lithium
Mood Stabilizer
Maintenance Tx of Bipolar Disorder
Slow onset
MOA: stabilization of post-synaptic terminal
Thiazide and Loop Diuretics can diminish Li clearance
Valproic acid
Tx of acute mania
Carbamezepine
Tx of acute mania
