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Neuro Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Phenelzine

A

Non-selective MAO-A and MAO-B Inhibitor (Irreversible)

MAO-A: targets tyramine, NE, 5HT, DA
MAO-B: targets DA

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2
Q

Tranylcypromine

A

Non-selective MAO-A and MAO-B Inhibitor (Irreversible)

MAO-A: targets tyramine, NE, 5HT, DA
MAO-B: targets DA

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3
Q

Selegiline

A

MAO-B Inhibitor (Irreversible) at low dose
Non-selective MAO-I at high dose

Rx: low dose – Parkinson’s, high dose – antidepressant (patch to prevent 1st pass effect)

MAO-A: targets tyramine, NE, 5HT, DA
MAO-B: targets DA

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4
Q

Imapramide

A

TCA
MOA: block re-uptake of 5HT and NE by inhibition of SERT and NET

Rx: enuresis

SE: lethal cardiac arrhythmias

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5
Q

Desipramide

A

TCA
MOA: block re-uptake of 5HT and NE by inhibition of SERT and NET

Rx: Neuorpathic pain

SE: lethal cardiac arrhythmias

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6
Q

Amitriptyline

A

TCA
MOA: block re-uptake of 5HT and NE by inhibition of SERT and NET

Sedative effects

SE: lethal cardiac arrhythmias

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7
Q

TCA overdose

A

Convulsions, Coma, Cardiac arrhthmias

Can be FATAL.

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8
Q

Fluoxetine

A

SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal

SE: GI disturbances, ↓ sexual function, headaches, sleep changes

Rx: major depression, GAD, PTSD, OCD

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9
Q

Sertraline

A

SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal

SE: GI disturbances, ↓ sexual function, headaches, sleep changes

Rx: major depression, GAD, PTSD, OCD

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10
Q

Paroxetine

A

SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal

SE: GI disturbances, ↓ sexual function, headaches, sleep changes

Rx: major depression, GAD, PTSD, OCD

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11
Q

Citalopram

A

SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal

SE: GI disturbances, ↓ sexual function, headaches, sleep changes

Rx: major depression, GAD, PTSD, OCD

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12
Q

Escitalopram

A

SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal

SE: GI disturbances, ↓ sexual function, headaches, sleep changes

Rx: major depression, GAD, PTSD, OCD

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13
Q

Fluvoxamine

A

SSRI
MOA: selectively inhibit SERT and block reuptake of 5-HT into presynaptic terminal

SE: GI disturbances, ↓ sexual function, headaches, sleep changes

Rx: major depression, GAD, PTSD, OCD

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14
Q

Venlafaxine

A

SNRI
MOA: Inhibit SERT and NET transporters

Rx: severe depression

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15
Q

Duloxetine

A

SNRI
MOA: Inhibit SERT and NET transporters

Rx: chronic pain

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16
Q

Trazodone

A

5-HT2 Antagonist
MOA: Inhibition of 5HT-2A receptors

Rx: insomnia

SE: blocks H1 receptor (sedation), cases priapism (prolonged, painful erection)

17
Q

Bupropion

A

Other Antidepressant
MOA: Blocks DA and NE reuptake

Rx: Smoking Cessation

18
Q

Mirtazapine

A

Other Antidepressant
MOA: Blocks presynaptic alpha-2 adrenergic autoreceptors, ↑ synaptic release of 5HT and NE; antagonist of 5HT3 and 5HT2 receptors (anti-emetic); blocks H1 (sedation, weight gain)

19
Q

Lithium

A

Mood Stabilizer
Maintenance Tx of Bipolar Disorder
Slow onset

MOA: stabilization of post-synaptic terminal

Thiazide and Loop Diuretics can diminish Li clearance

20
Q

Valproic acid

A

Tx of acute mania

21
Q

Carbamezepine

A

Tx of acute mania

Neuro Pharmacology (11 decks)

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