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Neuro Pharmacology > Neurodegenerative Disorder Agents > Flashcards

Neurodegenerative Disorder Agents Flashcards

1
Q

Donepezil

A

Cholinesterase Inhibitor

MOA: Inhibits AchE

Rx: Alzheimer’s only

Long half-life

SE: Bradycardia

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2
Q

Rivastigmine

A

Cholinesterase Inhibitor

MOA: Inhibits AchE and Butyrylcholinesterase

Rx: Alzheimer’s

Transdermal Patch

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3
Q

Galantamine

A

Cholinesterase Inhibitor

Rx: Alzheimer’s

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4
Q

Cholinesterase Inhibitor Side Effects

A 
SLUDGE
Salivation
Lacrimation
Urinary Incontinence
Diarrhea
GI cramps
Emesis
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5
Q

Memanthine

A

Non-competitive antagonist of NMDA glutamate receptor

MOA: reduces intracellular Ca influx and glutamate-induced excitotoxicity

Rx: severe Alzheimer’s (Tx of cognitive symptoms)

Use alone in severe AD or in combo w/ AChE

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6
Q

AD accumulations

A

Beta-amyloid plaques

Tau protein neurofibrillary tangles

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Neuro Pharmacology (11 decks)

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