opioid agonists Flashcards
1
Q
CYP2D6 drug interactions
A
cimetidine paroxetine fluoxetine duloxetine setraline amiodarone ritonavir
2
Q
CYP3A4 metabolized opioids
A
oxycodone tramadol methadone buprenorphine fentanyl alfentanil sulfantanil
3
Q
CYP3A4 interactions
A
macrolides grapefruit juice azoles carbamazepine St. John's wort rifampin
4
Q
glucuronidation
A
morphine
hydromorphone
oxymorphone
tapentadol
5
Q
morphine
A
phenanthrene naturally occurring fast first pass metabolism ( renal excretion -M-6-G->potent -M-3-G- no analgesia-hallucinations AE: myoclonas, pruritis
6
Q
hydromorphone
A
phenanthrene
semisynthetic
glucuronidation-kidney excretion
AE myoclonus
7
Q
codeine
A
phenanthrene
naturally occurring
cyp2d6 metabolism
8
Q
Fentanyl
A
phenylpiperidine synthetic lipophilic-> good transdermal/mucosal (92%) 75% taken up in lungs Cyp3A4 good choice with renal impairment
9
Q
oxycodone
A
phenanythrene semisynthetic good oral available and bioavailability (87%) CYP2D6 and CYP34A low dose is good for renal impairment
10
Q
methadone
A
diphenylheptane synthetic ATP binding cassette P-glycoprotein BBB restriction CYP3A4 good choice for renal impairment
11
Q
hydrocodone
A
phenanthrene
semisynthetic
CYP2D6
good for renal impairment
12
Q
meperidine
A
phenylpiperidine synthetic avoid with renal impairment -normeperidine metabolite causes seizures AE myoclonus
13
Q
cyp2D6 metabolized opioids
A
oxycodone tramadol hydrocodone tapentadol codeine
