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MOHD IV > antivirals > Flashcards

antivirals Flashcards

1
Q

enfuvirtide

A

anti HIV
blocks gp41, blocks entry
peptide
AE: expensive, local inflammation

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2
Q

AZT

A

HIV

NRTI

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3
Q

frequently used NRTI

A

ABC-abacorivir-G
FTC- emtricictabine -C
3TC- lamivudine-C

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4
Q

tenofovir

A

HIV
A analog
competes with other nucleotide analogs for renal exretion

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5
Q

nevipine, efavirenz, delavirdine

A

anti hiv
small molecure RTI
allosteric hydrophobic pocket

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6
Q

dolutegravir (DTG)

A

HIV

integrase inhibitor

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7
Q

darunavir, ritovir

A

HIV
protease inhibitor
AE lipodystrophy
ritovir- cyp3a4

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8
Q

HAART formula

A

2 NRTI + (protease or integrase or NNRT inhibitor) + phamokinetic enhancer (ritomavir)

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9
Q

acyclovir, valacyclovir

A 
alpha herps tx
nucleotide analogs
selective> requires viral thimidine kinase
tx
-HSV1 and 2 primary and reactivation
-VSV in immunocompromized 
-BMT, organ tx prophylaxis
-HSV encephalitis
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10
Q

famciclovir

A

slightly different action than acyclovir
alpha herps
G analog

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11
Q

cidovir, adefovir

A 
alpha herps
C analog
affective against Thimidine kinase - strains
competive inhibitor of DNA polymerase
-chain termination
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12
Q

foscarnet

A

all herps
pyrophosphate analog
non competitive inhibition of DNA polymerase
100x more selective for viral than human

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13
Q

docosanol

A

alpha herps
saturated fatty acid alcohol
topical
mixed evidence

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14
Q

gancyclovir

A

Beta and gamma herps

AE granulocytopenia and thrombocytopenia

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15
Q

fomivirsen

A

CMV
antisense RNA
tx CMV retinitis in immunocompromized patients

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16
Q

Beta and Gamma tx

A 
gancyclovir
valgancyclovir
foscarnet
cidofovir
fomivirsen
17
Q

amantadine

A 
influenza A
blocks M2 proton pump
>blocks uncoating event
no longer effective
within 48 hours of symptoms
alternative tx anti parkinsons
18
Q

zanamivir, oseltemivir

A

influenza A
neurimidase Inhibitor
prevent final step of life style

19
Q

palivizumab (synagis)

A

RSV
monoclonal antibody
at risk, infants under 2

20
Q

ribvarin

A 
most broad spectrum AV
RSV
interferes with several guanosine dependent processes
>highly defective viral genome
>CDt4 Th2> Th1
21
Q

tenovir

A

HBV
HIV RTI
well tolerated

22
Q

entecavir

A

HBV
G analog
failed HIV NRTI

23
Q

interferon alpha 2a

A

HBV

30-40% response

24
Q

HCV agents

A

simeprevir, parataprevir > protease inhibitor
ombitasivir, lidipasvir> phosphophoprotein
sofosbuvir, dasabuvir> polymerase inhibitor

25
Q

maravir

A 
anti HIV
only antiviral that targets a host protein (CCR5)
blocks entry
resistance: mutation of gp120
salvage tx

MOHD IV (12 decks)

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