antivirals

Question 1

enfuvirtide

Answer 1

anti HIV
blocks gp41, blocks entry
peptide
AE: expensive, local inflammation

Question 2

AZT

Answer 2

HIV

NRTI

Question 3

frequently used NRTI

Answer 3

ABC-abacorivir-G
FTC- emtricictabine -C
3TC- lamivudine-C

Question 4

tenofovir

Answer 4

HIV
A analog
competes with other nucleotide analogs for renal exretion

Question 5

nevipine, efavirenz, delavirdine

Answer 5

anti hiv
small molecure RTI
allosteric hydrophobic pocket

Question 6

dolutegravir (DTG)

Answer 6

HIV

integrase inhibitor

Question 7

darunavir, ritovir

Answer 7

HIV
protease inhibitor
AE lipodystrophy
ritovir- cyp3a4

Question 8

HAART formula

Answer 8

2 NRTI + (protease or integrase or NNRT inhibitor) + phamokinetic enhancer (ritomavir)

Question 9

acyclovir, valacyclovir

Answer 9

alpha herps tx
nucleotide analogs
selective> requires viral thimidine kinase
tx
-HSV1 and 2 primary and reactivation
-VSV in immunocompromized 
-BMT, organ tx prophylaxis
-HSV encephalitis

Question 10

famciclovir

Answer 10

slightly different action than acyclovir
alpha herps
G analog

Question 11

cidovir, adefovir

Answer 11

alpha herps
C analog
affective against Thimidine kinase - strains
competive inhibitor of DNA polymerase
-chain termination

Question 12

foscarnet

Answer 12

all herps
pyrophosphate analog
non competitive inhibition of DNA polymerase
100x more selective for viral than human

Question 13

docosanol

Answer 13

alpha herps
saturated fatty acid alcohol
topical
mixed evidence

Question 14

gancyclovir

Answer 14

Beta and gamma herps

AE granulocytopenia and thrombocytopenia

Question 15

fomivirsen

Answer 15

CMV
antisense RNA
tx CMV retinitis in immunocompromized patients

Question 16

Beta and Gamma tx

Answer 16

gancyclovir
valgancyclovir
foscarnet
cidofovir
fomivirsen

Question 17

amantadine

Answer 17

influenza A
blocks M2 proton pump
>blocks uncoating event
no longer effective
within 48 hours of symptoms
alternative tx anti parkinsons

Question 18

zanamivir, oseltemivir

Answer 18

influenza A
neurimidase Inhibitor
prevent final step of life style

Question 19

palivizumab (synagis)

Answer 19

RSV
monoclonal antibody
at risk, infants under 2

Question 20

ribvarin

Answer 20

most broad spectrum AV
RSV
interferes with several guanosine dependent processes
>highly defective viral genome
>CDt4 Th2> Th1

Question 21

tenovir

Answer 21

HBV
HIV RTI
well tolerated

Question 22

entecavir

Answer 22

HBV
G analog
failed HIV NRTI

Question 23

interferon alpha 2a

Answer 23

HBV

30-40% response

Question 24

HCV agents

Answer 24

simeprevir, parataprevir > protease inhibitor
ombitasivir, lidipasvir> phosphophoprotein
sofosbuvir, dasabuvir> polymerase inhibitor

Question 25

maravir

Answer 25

``` anti HIV only antiviral that targets a host protein (CCR5) blocks entry resistance: mutation of gp120 salvage tx ```