Opiate Overdose Flashcards

1
Q

what is an opioid

A

a synthetic or natural agent which stimulates opioid receptors producing opium life effects

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2
Q

what are different types of opiates

A

codeine
morphine
heroin

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3
Q

why do people become addicted to opiates

A

due to the euphoric effect

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4
Q

where are opiates derived from

A

opium poppy, papaver somniferum

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5
Q

what happens with an opiate overdose

A

CNS + respiratory depression resulting miosis (constriction) and apnoea

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6
Q

what are the effects of opiates on the brain

A

euphoria
sedation
chronic painkiller

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7
Q

what mental health condition is associated with opiate use

A

depression

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8
Q

what are the effects of opiates on the respiratory system

A

respiratory depression

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9
Q

what are the effects of opiates on the GI system

A

slows digestion leading to constipation

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10
Q

what are the effects of opiates on the nervous system

A

if used chronicly can lead to hyperalgesia (syndrome of increased sensitivity to pain)

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11
Q

what are the effects of opiates on the immune system

A

immunosuppression (infection)

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12
Q

what are the effects of opiates on the liver

A

liver damage

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13
Q

which opioid is most associated with mortality

A

heroin

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14
Q

epi

A

most common in young males who are IV heroin users

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15
Q

aetiology

A
complications of substance abuse in regular users or abusers
unintential overdose
intential overdose (suicide)
iatrogenic overdose
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16
Q

what defines a severe opioid overdose

A

life threatening respiratory depression

17
Q

risk factors

A

opioid abuse and dependence

recent abstinence in chronic users (ex-prisoners)

18
Q

why are ex-prisoners more likely to have an opiod overdose

A

abstinence while in prison so their tolerance decreases

19
Q

what are features of an opioid overdose

A

miosis (constriction)
bradypnoea (respiratory depression)
drowsy and sleepy

20
Q

what response is there to naloxone

A

dramatic response to naloxone which blocks the effects of opioids

21
Q

what is the diagnostic test for opioid overdose

A

response to naloxone

22
Q

how is opioid overdose diagnosed

A

history and examiantion

23
Q

what is the triad of findings which indicate opioid overdose

A

1 CNS depression (sleepiness or drowsiness)
2 respiratory depression
3 miosis (constriction)

24
Q

a patient with QRS prolongation and features of opiate overdose is most likely to have taken what drug

A

propoxyphene

25
Q

what is the first line investigation and gold standard investigation for opioid overdose

A

naloxone with reversal of overdose signs