Ophthal Flashcards
What is the difference between anterior and posterior uveitis?
Anterior - inflammation of the iris
Posterior - inflammation of the choroid
What are the risk factors for uveitis?
Autoimmune disease
HLA-B27
Intra-ocular lymphoma
Idiopathic
What are the symptoms of anterior uveitis?
Pain
Redness
Photophobia
Diplopia
What are the symptoms of posterior uveitis?
Gradual visual loss
Blurred vision
Absence of anterior symptoms
What is seen on fundoscopy in anterior uveitis?
Diffuse conjunctival injection
Hazy aqueous
Anterior synechiae
Keratitic precipitates on cornea
What is seen on fundoscopy in posterior uveitis?
Inflammatory cells in the vitreous
Oedeomatous optic nerve and disc
What is the treatment of uveitis?
Topical/PO steroids
Cyclopentolate (cycloplegic-mydriatic drug) to paralyse ciliary body, relieve pain and prevent adhesions
What are the features of episcleritis?
Mild pain/discomfort
Grittiness
Watering
What is the most common type of scleritis?
Anterior
What are the risk factors for scleritis?
RA and GPA
CTDs
Sarcoid
UC
What are the features of scleritis?
Severe boring pain radiating to forehead/jaw
Localised or diffuse red eye
Gradual decrease in vision
What are the signs of scleritis?
Reduced visual acuity
Bluish tinge to sclera
Sectoral or diffuse redness
Tender globe
What percentage of scleritis patients have a systemic vasculitis?
15%
How is scleritis diagnosed?
B-scan USS of globe
What is the treatment of scleritis?
PO NSAIDs –> PO pred –> MTX/AZA
If necrotising, skip furst step
What are the 3 types of blepharitis?
Staphylococcal
Seborrhoeic
Meibomian
What are the complications of scleritis?
Scleral thinning
Raised IOP
Retinal detachment
Phthisis (globe atrophy)
What is chalazion?
Meibomian cyst
What is madarosis?
Loss of eyelash
How can you differentitate keratitis from uveitis?
Normal pupillary reaction in keratitis
How is herpes simplex keratitis diagnosed?
Dendritic corneal ulcer - fluoroscein stainin
What is orbital cellulitis?
Infection of the fat and muscles posterior to the orbital septum, within the orbit but not involving the globe
What is periorbital cellulitis?
Infection anterior to the orbital septum
What is the clinical difference between orbital and periorbital cellulitis?
In periorbital - no visual changes, proptosis, ophthalmoplegia, or pain with eye movements
How is orbital cellulitis diagnosed?
CT with contrast
Swab
Blood cultures
What is seen on examination in orbital cellulitis?
Reduced visual acuity
Afferent pupillary defect
Proptosis
Oedema and erythema
Where do the changes of macular degeneration occur?
Central area of retina - macula
What are the characteristics of dry AMD?
Soft drusen (Yellow round spots in Bruch's membrane) Atrophy and changes to pigment of the retinal pigment epithelium (RPE)
What are the characteristics of wet AMD?
New blood vessels grow in from the choriocapillaris under the retina
They spread around the RPE, are fragile and leak easily
Cause disciform scarring
Name 5 risk factors for AMD?
Smoking Age Family history Obesity AMD in one eye
How does AMD present?
Scotoma
Reduced visual acuity particularly for near vision
Decreased contrast, colour, dark adaptation
Photopsia and light glare
Wet - diplopia and distortion
How is dry AMD diagnosed?
Distortion of Amsler grid lines
Fundoscopy - drusen, yellow macular scar, hypo/hyperpigmentation of RPE
How is wet AMD diagnosed?
Well demarcated red patches - retinal/sub RPE haemorrhages
Fluorescein angiography
What does colour fundus photography do?
Records the appearance of the retina
What is the treatment of dry AMD?
Stop smoking
Zinc with vit A, C, E reduce progression in 1/3
For which patients is zinc and anti-oxidants contraindicated?
Smokers - beta-carotene increases risk of lung cancer
What is the treatment of wet AMD?
Intra-vitreal anti-VEGF e.g. ranibizumab
Laser photocoagulation
What is VEGF?
Pro-angiogenic growth factor which stimulates vascular permeability
What is damaged in glaucoma?
Optic nerve head
Loss of retinal ganglion cells and axons
What is raised intra-ocular pressure?
> 21mmHg
What are the causes of secondary glaucoma?
Inflammatory e.g. with uveitis Phacogenic (caused by capsular rupture of the lens) Intra-ocular haemorrhage Steroid induced Traumatic
What are the characteristics of absolute glaucoma?
NO vision
Pupillary reflex lost
Stony eye
Painful +++
What part of the eye produces aqueous humour?
Ciliary body