Online Med ed--Surgery Flashcards
Causes of hyperkalemia
Iatrogenic Ingestion + CKD (esp .ESRD) low-aldosterone states artifact (hemolysis) ACE-i/ARB Aldo-i
EKG signs and tx of unstable hyperkalemia
wide QRS or peaked T wave
Requires emergent therapy with (1) stabilization of cell membrane–IV Ca
(2) temporize–insulin + D5
(3) Decrease total body K–loop diuretics or K-exylate if has CKD and cant get diuretics
Chronic therapy with HD
Causes of hypokalemia
Renal vs GI
Renal–hyper-aldo
diuretics (thiazide and loop)
GI–vomiting and diarrhea
How much does 10meq K rais K
0.1
uric acid stones (2 causes and txs)
radiolucent
Gout (allupurinol)
tumor lysis syndrome (rasburicase)
Triad for renal cell carcinoma and complications
flank pain, flank mass, hematuria
NOTE: only 30% have all three
Complications
May have EPO-producing tumor–polycythemia
Bleeding–> anemia
thrombosis of renal vein
Cysts associated with autosomal dominant polycystic idney disease
non-radially oriented cysts in kidneys
liver
pancreas
berry aneurysms (should be screened)
Causes of respiratory acidosis
hypoventilation 2/2 asthma COPD obesity OSA opiate overdose decreased muscular strength
Causes of respiratory alkylosis
hypoxia
anxiety
Causes of metabolic alkalosis
(1) contraction alkylosis (urine chloride low) 2/2 volume depletion 2/2diuretics, emesis, dehydration
NOTE: emesis also causes gastric acid loss
(2) Non-volume responsive conditions (Barter syndrome, hyperaldo)
NOTE: high urine chloride
Causes of nonanion gap acidosis
2 categories depending on presence of urine anion gap (Na+K-Cl)
If UAG positive –> rta
If UAG negative –> diarrhea
Causes of metabolic acidosis
Methanol Uremia DKA Propylene Isopropyl Lactic acid Ethylene glycol Salicylates
Microcytic anemia: types
iron deficiency anemia
anemia of chronic disease
thalasemia
sideroblastic anemia
Iron deficiency anemia: Labs and tx
low iron
low ferritin
high TIBC
Seen in older men with colon cancer or women with menorrhagia
Tx: ferrous sulfate and senna
Anemia of chronic disease: Labs and tx
low iron
high ferritin (as this is an acute phase reactant))
low TIBC
Seen in people with chronic disease/infection
Tx: underlying disease or EPO
Thalessemia: Labs and tx
Problem is with hgb, NOT iron
nl iron, ferritin, and TIBC BUThgb electrophoresis abnl
2 types alpha and beta
Tx: deferoxamine
Sideroblastic anemia: labs and causes
high iron
nl ferritin
nl TIBC
PBS showing ringed sideroblasts
reversible causes: certain meds, alcohol, and lead
irreversible causes: B6 deficiency, MDS
Production anemias: 2 types
microcytic and macrocytic
RI < 2%
Causes of B12 deficiency
Nutritional deficiency (rare as have 3-10 years of storage)
pernicious anemia (no intrinsic factor) crohns disease (affects distal small bowel) gastric bypass
Can be distinguished by Schillings test
4 Labs to distinguish causes of normocytic anemia
LDH
Haptoglobin
bili
smear
Types of normocytic anemias
hemolytic (PNH, G6PD def, sickle cell, AIHA, HS)
Autohemolytic anemia: 2 types
Cold: IgM mediated associated with mycoplasma and mono and treated by avoiding cold
Warm: IgG mediated associated with autoimmune disease and cancer, and treated with steroids, rituximab, and splenectomy
NOTE: positive coombs for both
What to do when WBC> 60K but patient asyx
Assume chronic leukemia and Get diff –>
high PMNS means CML and needs tx with imatinib
high lymphocytes, then CLL and needs HSCT or chemo
Acute leukemias clinical presentation and labs
infection and fever
anemic
bleeding
bone pain
WBC may not be elevated
Get PBS to distinguish AML(pmns) from ALL(lymphs)