Online Med ed--Surgery Flashcards
Causes of hyperkalemia
Iatrogenic Ingestion + CKD (esp .ESRD) low-aldosterone states artifact (hemolysis) ACE-i/ARB Aldo-i
EKG signs and tx of unstable hyperkalemia
wide QRS or peaked T wave
Requires emergent therapy with (1) stabilization of cell membrane–IV Ca
(2) temporize–insulin + D5
(3) Decrease total body K–loop diuretics or K-exylate if has CKD and cant get diuretics
Chronic therapy with HD
Causes of hypokalemia
Renal vs GI
Renal–hyper-aldo
diuretics (thiazide and loop)
GI–vomiting and diarrhea
How much does 10meq K rais K
0.1
uric acid stones (2 causes and txs)
radiolucent
Gout (allupurinol)
tumor lysis syndrome (rasburicase)
Triad for renal cell carcinoma and complications
flank pain, flank mass, hematuria
NOTE: only 30% have all three
Complications
May have EPO-producing tumor–polycythemia
Bleeding–> anemia
thrombosis of renal vein
Cysts associated with autosomal dominant polycystic idney disease
non-radially oriented cysts in kidneys
liver
pancreas
berry aneurysms (should be screened)
Causes of respiratory acidosis
hypoventilation 2/2 asthma COPD obesity OSA opiate overdose decreased muscular strength
Causes of respiratory alkylosis
hypoxia
anxiety
Causes of metabolic alkalosis
(1) contraction alkylosis (urine chloride low) 2/2 volume depletion 2/2diuretics, emesis, dehydration
NOTE: emesis also causes gastric acid loss
(2) Non-volume responsive conditions (Barter syndrome, hyperaldo)
NOTE: high urine chloride
Causes of nonanion gap acidosis
2 categories depending on presence of urine anion gap (Na+K-Cl)
If UAG positive –> rta
If UAG negative –> diarrhea
Causes of metabolic acidosis
Methanol Uremia DKA Propylene Isopropyl Lactic acid Ethylene glycol Salicylates
Microcytic anemia: types
iron deficiency anemia
anemia of chronic disease
thalasemia
sideroblastic anemia
Iron deficiency anemia: Labs and tx
low iron
low ferritin
high TIBC
Seen in older men with colon cancer or women with menorrhagia
Tx: ferrous sulfate and senna
Anemia of chronic disease: Labs and tx
low iron
high ferritin (as this is an acute phase reactant))
low TIBC
Seen in people with chronic disease/infection
Tx: underlying disease or EPO
Thalessemia: Labs and tx
Problem is with hgb, NOT iron
nl iron, ferritin, and TIBC BUThgb electrophoresis abnl
2 types alpha and beta
Tx: deferoxamine
Sideroblastic anemia: labs and causes
high iron
nl ferritin
nl TIBC
PBS showing ringed sideroblasts
reversible causes: certain meds, alcohol, and lead
irreversible causes: B6 deficiency, MDS
Production anemias: 2 types
microcytic and macrocytic
RI < 2%
Causes of B12 deficiency
Nutritional deficiency (rare as have 3-10 years of storage)
pernicious anemia (no intrinsic factor) crohns disease (affects distal small bowel) gastric bypass
Can be distinguished by Schillings test
4 Labs to distinguish causes of normocytic anemia
LDH
Haptoglobin
bili
smear
Types of normocytic anemias
hemolytic (PNH, G6PD def, sickle cell, AIHA, HS)
Autohemolytic anemia: 2 types
Cold: IgM mediated associated with mycoplasma and mono and treated by avoiding cold
Warm: IgG mediated associated with autoimmune disease and cancer, and treated with steroids, rituximab, and splenectomy
NOTE: positive coombs for both
What to do when WBC> 60K but patient asyx
Assume chronic leukemia and Get diff –>
high PMNS means CML and needs tx with imatinib
high lymphocytes, then CLL and needs HSCT or chemo
Acute leukemias clinical presentation and labs
infection and fever
anemic
bleeding
bone pain
WBC may not be elevated
Get PBS to distinguish AML(pmns) from ALL(lymphs)
Acute myeloid leukemia
“young neutrophils in the bloo”
disease of older people with benzene exposure
Dx: smear and BM biopsy showing > 20% blasts
myeloperoxidase postive
Tx: if M3 (auer rods), treat with vit A. if not, chemo
Acute Lymphocytic Leukemia
“young lympocytes in the blood”
young pt
Dx with smear and postive BM biopsy for > 20% blasts that are positive for tdt
Tx with radiation
Chronic myeloid leukemia
older patient
Diff and BM biospy showing BCR-ABL translocation
Tx with imatinib
Chronic lymphocytic leukemia
patient older
dx with diff and bm bx
if asx, do nothing
if sx and old, chemo
if sx and young, HSCT
Post-op fever: 7 possible causes (Tx)
Right after–bacteremia (broad spectrum antbx)
Everything else: 5 Ws
Wind
POD#1–atelectasis (prevent with IS and getting out of bed)
POD#2–PNA (broad antbx)
Water
POD#3 UTI (antbx)
Walking
POD#5 DVT/PE (heparin to warfarin or NOAC)
Wound
POD#7 cellulitis (clinda)
POD#10-14 abscess (abx +I/D)
NOTE: 5th W is wonder drugs including anesthesia that can cause malignant hyperthermia intra-op and bactrim that could cause AIN and fever)
2 Electrolyte culprits for post-op AMS
Na and Ca
Causes of AMS post op (4)
electrolyte disturbance
sundowning in elderly
hypoxemia (think PE/PNA/ADS)
Delirium tremens (after 1 day HTN, tchy, diaphoresis then tremors 48-72hrs)
3 types of post-op abdominal distension + diagnosis/tx
(1) ileus (seen POD1-2, a functional issue) diagnosed by KUB showing diffuse dilation of small and large bowel
TX: IVF, get out of bed, give K
(2) Obstruction (seen POD 5 after ileus not getting better) diagnosed by KUB showing SBO/LBO with transition zone
TX: NG tube, surgery to target likely adhesions
(3) Olgivie Syndrome–dilated elderly colon seen on KUB
TX: rectal tube, stigmine, colonoscopy
5 causes of post-op fistula
Foreign body Epitheliazation Tumor Irridation/inflamed/inflammatory bowel Distal obstruction
FETID
Risk factors with cholelithiasis
Fat
Female
Fertile
Forty
Also, being American indian
Alternative tx for cholelithiasis other than cholecystectomy
ursodeoxylic acid
Cholecystitis defintion and presentation + tx
gallstone(s) in cystic duct
Pt with CONSTANTRUQ pain and murphys sign
tx with IVF, abx, and urgent cholecystectomy
RUQ US in cholecystitis shows ___
(1) pericholecystic fluid
(2) thickened gb wall
(3) gallstones (sometimes wont see)
If you don;t see what you want, get HIDA
Choledocolithiasis definition, presentation, and tx
gallstone in CBD
Presents with painful jaundice with murphys sign, fever, and leukocytosis +/- pancreatitis or hepatitis
TX: NPO, IVF, IVabx, urgent ERCP to get stone and elective cholecystectomy
Dx of choledocolithiasis
RUQ US showing obstruction or CBDdilation
if negative, get MRCP or ERCP (if suspicion really high)
Cholangitis presentation
charcots triad (RUQpain, jaundice, and fever)
if also hypotensive and obtunded, reynolds pentad
NOTE: jump to emergent ERCP from RUQUS and IVabx with urgent cholecystectomy
Abx treatment of emergent gallbladder diseases
cholecytitis, choledocolithiasis, cholangitis
cipro (GNRs) + metronidazole (anaerobes)
amp-gent +metronidazole
NOT pip-tazo
Painless jaundice: causes
Prehepatic (hemolysis or hematoma) –> unconjugated
Intrahepatic (genetic, hepatitis) –> mixed unconjugated and conjugated
post-hepatic (cancer +/- strictures) –> conjugated
Extended gallbladder and massively dilated CBDon RUQUS indictaes ____
cancer/stricture
Presentations of obstructive jaundice
(1) painless jaundice
(2) wt loss and clay-colored stool
(3) distended, nonpainful gallbladder
Migratory thrombophlebitis =
Pancreatic cancer
Risk factors for cholangiocarcinoma
chronic untreated cholecystitis
PSC (MRCPshowing beads on a string)
Presentation of someone with obstructive jaundice, postive FOBT, and negative colonoscopy indicates ____
tumor of ampulla of vater
Progression of tx of GERD and complications
GERD–PPI
Barrets–high dose PPI
dysplasia–ablation
adenocarcinoma–resection
Note: nissen fundoplication is surgical tx for GERD that does not get better with PPI
Achalasia: presentation, diagnosis, and tx
presentation: dysphagia for solids
Dx: Barium swallow or manometry
Tx: botox, dilation, or *myotomy
*best initial treatment
Mallory weiss tear vs boorhaves
Mallory weiss: superficial tear, associated with cocaine and alc use, treat initially like GIbleed although is self-limited
Boorhaves: transmural tear, air in chest –> mediastinitis, hammands crunch (crepitus with heart beat), dx gastrografin swallow (not as caustic to mediastinum) –>MBS –> EGD, tx with emergent surgery
esophageal cancer: types
SCC–upper third, hot liquids and smoking
adenocarcinoma–lower third, GERD
Constipation vs obstipation
Seen as a progression in SBO: constipation (no loss of function, still peristalsis resulting in high-pitched sounds) –> obstipation (loss of function, hypoactive/no BS)
Imaging that shows complete vs incomplete SBO
CT scan
4 types of hernias
Direct inguinal (adult males)
Indirect inguinal (baby males)
Femoral (adult females)
Ventral (post-op, risk factor is dehiscence)
Carcinoid (gut)
neuroendocrine tumor found in gut or lung that releases serotonin and mets to liver
sxs: flushing, wheezing, diarrhea, right-sided cardiac fibrosis (lungs break down 5HT)
Dx: urine 5-HIAA then CTscan to identifies lesions
3 most common causes of acute pancreatitis
alcohol
gallstones
hypertriglyceridemia
Tx of necrotizing pancreatitis
carbapenams after confirmaion with FNA
Pancreatic pseudocyst management
presents with early satiety, wt loss, and abd pain
CTscan to confirm
if <6cm and <6wks: uncomplicated–>watch and wait to see if will resolve
if >6wks or >6cm: complicated–> drain
Complications of acute pancreatitis
pseudocyst
necrotization
abscess
Indications of colorectal cancer
man with IDA
advanced cancer
#stool caliber (left-sided)
alternating constipation and diarrhea (right-sided)
wt loss
Anal cancer: treatment
Regardless of stage: chemo and radiation (nigro protocol)
Polinoidal cyst
anal cyst resulting from clogged hair follicle
can lead to abscess
tx with I/D if abscess, then resection
Ischemic bowel: presentation
pain out of proportion to exam
bloody BM
Sepsis
risk factors: CAD, afib, ischemia
Nonspecific abdominal pain: etiologies to be suspicious for depending on h/o and risk factors
DKA
MI
constipation
5 types of leg ulcers
(1) Compression: from pressure points (bedridden or wheelchair bound pt) so where bone is close to skin (shoulders, heels, sacrum)
(2) Diabetic: from microvascular changes causing neuropathy, heels or balls of feet
(3) arterial insufficiency: from PAD and macrovascular in nature (hairless legsm shny/scaly skin), absent pulses, tips of toes
(4) venous stasis: CHF, cirrhosis, nephrotic syndrome –> edema, induration, and hyperpigmentation, medial malleolus
(5) Marjolin: SCC presenting as ulcer with sinus tract or old wound
actinic keratosis
on continuum of SCC. 1% transformation per year
cryo, excision
lesion characterized by erythematous base with scaling, nonpigmented (looks very similar to SCC)
early mucosal form of SCC
leukoplakia
Basal cell carcinoma
cancerous lesion with waxy borders, erythamtous, easy to bleed, and with many telactasias
types of melanoma
superficial spreading
nodular
lentigo malignant
acral lentiginous (most dangerous but most easily missed as often in unexposed areas)
Higher lifetime estrogen with ____
early menarche
late menopause
nulliparity
hormone replacement tx (but NOT OCPs)
Work-up of breast cancer
Mammogram at 50yo q2yr for general population
MRI if high risk (BRCA1/2, prior radiation)
core biopsy if mammogram or MRI positive
tamoxifen vs raloxifen
tamoxifen: works better in breast cancer tx, works as estrogen receptor agonist in uterus –> endometrial carcinoma, can also cause DVT
raloxifen: works as estrogen receptor antagonist in breast, not as many adverse effects
Most likely etiology to sudden-onset severe unilateral lower abdominal pain immediately following strenous or sexual activity
ruptured ovarian cyst
NOTE: USwill show pelvic free fluid
psoas sign
abdominal pain with hip extension, indicative of psoas abcesess
Features of a meningioma
extra-axial, well-circumscribed, dural-based, partially calcified on neuroimaging
NOTE: considered benign, although can present due to mass effect
Features of biceps tendinopathy/rupture
anterior shoulder pain
pain with lifting, carrying, or overhead reaching
NOTE: weakness is less common
Emphysematous cholecystitis
life-threatening form of acute cholecystitis that occurs more commonly in immosuppressed pts and people with DM, arising d/t infection of gb with gas-forming bacteria (clostridium, E coli)
TX with emergent cholecystectomy
A patient with stuttering episods of N/V, pneumobilia, hyperactive bowel sounds, and dilated loops of bowel likely has___
gallstone ileus (form of mechanical SBO)
4 types of disease patterns of multiple sclerosis
relapsing-remitting (majority)
primary progressive
secondary progressive
progressive relapsing