Oncology late effects

Question 1

Chemotherapy side effects

Answer 1

Methotrexate –> bone marrow suppression (anemia, infections), hepatitis, osteoporosis
Corticosteroids –> usual steroid S/E
Cisplatin/carboplatin: cataracts, hearing impairment , bone marrow suppression , renal impairment
Bleomycin –> pulmunary fibrosis
Cyclofosphamide-haemorhagic cystitis, infertility
haematological malignancies
Vincristine –> peripheral neuropathy (foot drop, poor coordination, Rhomburg positive reduced senation/numbness/tingling, distal muscle weakness)
–> constipation

Alopecia
Mucositis
Oral candidiasis

Question 2

Radiotherapy side effects

Answer 2

Secondary malignancies: brain, thyroid, breast, upper GI, lung
Cardiomyopathy
Lung fibrosis
Ovarian failure
Radiation dermatitis
Poor growth
Osteoporosis
Avascular necrosis

Question 3

Bone marrow transplant side effects

Answer 3

Graft vs host disease
- rash
- liver (hepatitis, jaundice)
- GIT (nausea, vomiting, diarrhoea)

+ usual chemo side effects