Oncology drugs

Question 1

What are some side effects of tamoxifen?

Answer 1

hot flushes, weight gain, thromboembolism, endometrial hyperplasia

Question 2

how do chemotherapeutic agents work?

Answer 2

usually target a part of the cell cycle to prevent cell division and proliferation

Question 3

what are the endocrine drug of choice for breast cancer in post menopausal women?

Answer 3

aromatase inhibitors

Question 4

what are some bladder consequences of cyclophosphamide?

Answer 4

haemorrhagic cystitis

Question 5

what should also be prescribed with cyclophosphamide?

Answer 5

PCP prophylaxis- trimethoprim and sulfamethoxole (bactrim) unless contraindicated due to allergy

Question 6

what is the main mode of action of cyclophosphamide?

Answer 6

cytotoxic effects on lymphocytes

Question 7

what are the main SE of cytotoxic antineoplastic drugs?

Answer 7

alopecia, bone marrow suppression, damage to mucous membranes, delayed healing, teratogenicity

Question 8

what type of drug is methotrexate? how does it work?

Answer 8

Folic acid antagonist. Inhibits DNA synthesis and cell replication by competitively inhibiting the conversion of folic acid to folinic acid

Question 9

what are some SE of adriamycin?

Answer 9

cardiac toxicity

Question 10

what are some SE of oncovan?

Answer 10

peripheral neuropathy

Question 11

what is a SE of bleomycin?

Answer 11

pulmonary inflammation