Antivirals Flashcards
1
Q
which drugs do we use for herpes simplex virus and VZV?
A
aciclovir, famciclovir, valciclovir
2
Q
what is the difference between ganciclovir and valganciclovir?
A
valganciclovir is a prodrug of ganciclovir. is converted to ganciclovir via hydrolysis
3
Q
what do we use ganciclovir for?
A
CMV retinitis in immunosuppressed patients
4
Q
what do we use valganciclovir?
A
CMV retinitis in immunosuppressed patients and post organ transplant CMV prophylaxis
5
Q
what is a SE of ganciclovir?
A
bone marrow suppression
6
Q
how does acyclovir work
A
analogue of adenine and when it forms acyclovir triphosphate it is a competitive inhibitor of DNA polymerase in HSV infected cells
