Gastro drugs Flashcards
what diuretic (s) do we use for ascites management?
spironolactone +/- frusemide
what drug would you use for oesophageal varices?
Octreotide or terlipressin (terlipressin is used more frequently)
How does terlipressin work? What is it used for?
Constricts the splanchnic system to decrease the pressure of the portal system (vasoconstriction). So we would use it in oesophageal varices.
what drug other than terlipressin/octreotide would we prescribe for a patient who had oesophageal varices?
IV antibiotics (empiric). Treat possible septic precipitant for transient elevation in portal pressure
Side effects of sulfasalazine?
sulfapyridine intolerance, rash, fever, haemolysis, pancreatitis, oligospemia
what are some long term side effects on PPIs?
increased risk of CA pneumonia + increased risk of fracture
what is a short term side effect of PPIs?
headache
triple therapy for H pylori?
amoxycillin (or metronidazole for penicillin HS) + PPI + clarithromycin
SE of osmotic aperients?
dehydration and electrolyte disturbances secondary to diarrhoea
what is an adverse reaction to maxolon?
oculogyric gyrus. esp seen in younger patients
maxolon and stemitil are what drugs?
metoclopramide, and prochlorperazine respectively
we see sedation in which dopamine antagonists anti emetics?
stemitil because it is more centrally acting than maxolon
what 3 drugs could you use for travel sickness?
Stemitil (DA antagonist); Promethazine (antihistamine); hyoscine (anticholinergic)
what categories of anti emetics are there? Which one is first line?
- Dopamine antagonists (first line)
- Antihistamine- promethazine
- Anticholinergic- hyoscine
- 5HT3 antagonists- ondanestron
what drug do you prescribe for Wilson’s disease?
Penicillamine, a copper chelating drug
