Oncology Flashcards
t(1:19)
pre B ALL
t(8:14)
C-MYC - Burkitts
t(15:17)
Acute promyelocytic leukaemia
t(9:22)
Philadelphia - ALL, CML (POOR prognosis)
t(11:22)
Ewing’s
t(12:21)
ALL (GOOD prognosis)
t(11q:22)
Wilms
N MYC
Neuroblastoma (poor prognosis)
EGFR
Glioblastoma
1p
AML
10q (RET)
MEN2
INI1 deltion
Atypical teratoid rhabdoid tumour (ATRT)
15q mutation
Blood
p53 mutation
Soft tissue sarcoma/Li Fraumeni
11p deletion (WT1)
Wilms/WAGR
13q deletion (RB1)
Retinoblastoma
GATA1
AML in T21
RB2 Retinoblastoma
(2 hit Chr13) Osteosarcoma
p53 Li Fraumeni Syndrome
Bone, soft tissue, breast
NF1 Neurofibromatosis 1
Optic glioma, brain glioma, meningioma, neurofibroma, phaechromocytoma, sarcoma
NF2 Neurofibromatosis 2
Bilateral acoustic neuroma
WT1 Wilms, WAGR
Wilms, aniridia (no irs), genitourinary abnormalities, mental retardation)
Von Hippel Lindau
Renal cell carcinoma, phaeochromocytoma, pancreatic tumour
PTEN
Glioblastoma
INI1
Atypical Teratoid Rhabdoid Tumour (ATRT)
APC
Hepatoblastoma
MEN1
Pancreas, pituitary, parathyroid tumours
MEN 2A + 2B - RET
Phaechromocytoma, parathyroid adenoma, medullary thyroid carcinoma
Trisomy 21
Transient leukamoid reaction in newborn 10%
ALL increased risk 20%
AML increased risk 400%
Klinfelter syndrome (47XXY)
Breast cancer
Noonan Syndrome
Juvenile myelomonocytic leukaemia
Beckwith Weiderman/hemi-hypertrophy
Wilm’s tumour, hepatoblastoma
Fanconi anaemia
Leukaemia (especially AML)
Ataxia-telangectasia
Lymphoma, leukaemia
DiGeorge
Thymoma
Severe Combined Immunodeficiency
Leukaemia, lymphoma