Oncology

Question 1

Cancer med dosing is based off of what?

Answer 1

BSA mg/m2

Question 2

Which cancer med doesn’t dose based on BSA?

Answer 2

Carboplatin - AUC and CrCl

Question 3

Most common reaction with Mabs

Answer 3

anaphylaxis(injection) or SJS

-pretreat with APAP/antihist, steroid

Question 4

Chemo with least bone marrow suppression?

Answer 4

Asparaginase, Bleomycin, Vincristine

Question 5

What is used for Methotrexate toxicity?

Answer 5

Leucovorin

Question 6

Mab antibody type

Answer 6

omab = murine/mouse
umab = human
ximab = chimeric (some human, some not)
zumab = mostly human, some not

Question 7

most tyrosine kinase inhibitors (-nib) are what dosage form?

Answer 7

PO oral

Question 8

TKI class SE

Answer 8

diarrhea and rash
QTc prolongation
all CYP3A4

Question 9

Chemo with highest N/V(emetic) risk

Answer 9

Carboplatin, Cisplatin, Ifosfamide, Oxaliplatin

Question 10

Emend generics

Answer 10

Aprepitant (PO)

Fosaprepitant (IV)

Question 11

Cannabinoid anti-emetics

Answer 11

Dronabinol (PO) - CIII

Nabilone (PO)/Brand Cesamet - CII

Question 12

List of alternative or add-ons for anti-nausea

Answer 12

Dexamethasone, Haloperidol, Lorazepam, Olanzapine/Zyprexa, Prochlorperazine, Promethazine, Scopolamine

Question 13

GCSFs (stimulate Neutrophils)

Answer 13

Leukine (Sargramostim)
Neupogen (FIlgrastim)
Neulasta (Pegfilgrastim)
usually given 24-72 hrs after chemo

Question 14

ESAs - Stimulate RBCs

Answer 14

Epoetin (Procrit)
Darbepoetin (Aranesp)
only give if hemoglobin < 10
REMS ended 2017