Antibiotics

Question 1

Which FQ has low renal excretion (can’t be used for UTI?)

Answer 1

Moxifloxacin. For UTI use Levo or Cipro

Question 2

Which antibiotic has the highest risk of C Diff?

Answer 2

Clindamycin

Question 3

Normal WBC range

Answer 3

4,000-10,000 cells/mm3

Question 4

Which bacteria gram stain purple?

Answer 4

Gram + (cocci/bacilli)

Question 5

What class best treats SPICE bacteria (Gm -)?

Answer 5

CARBAPENEMs

SPICE: Serratia, Prov, Indole, Citrobacter, Enterobacter

Question 6

Concentration-dependent antibiotics

Answer 6

Aminoglycosides(Gent, Tob, Amikacin) and Fluoroquinolones

Question 7

Time-dependent antibiotics

Answer 7

Beta lactams, Vanc, Macrolides(azithro, erythro), Clindamycin

Question 8

Atypical coverage

Answer 8

Macrolide or respiratory FQ(not Cipro)

NOT Beta lactams
mycoplasma, chlamydia, legionella, rickettsia

Question 9

True or False: Macrolides have QTc prolongation

Answer 9

True (erythromycin is highest)

Question 10

Tetracycline: what to avoid?

Answer 10

Kids under 8, pregnancy/breastfeeding(teeth discolor), Don’t give Doxy with Penicillins

Question 11

Cipro is contraindicated with what?

Answer 11

Tizanidine

Question 12

What is the FQ Black Box Warning?

Answer 12

Tendon rupture, muscle weakness, peripheral neuropathy, CNS

Question 13

Pseudomonas(G-) treatment

Answer 13

AMGs (gentamicin, tobramycin, amikacin). Gent can have synergy against G+
Or Cefepine, Imipenem, Levofloxacin

Question 14

AMG warnings

Answer 14

avoid in pregnancy, ototoxic, Neurotoxic, Nephrotoxic, avoid with diuretics, avoid with SULFA allergy, electrolyte issues

Question 15

Carbapenems

Answer 15

Broad spectrum but no MRSA, VRE, or atypical coverage

Use Ertapenem against E Coli or Klebsiella

Question 16

Vancomycin

Answer 16

1st line for MRSA
100% renally eliminated
trough 15-20 usually (sometimes 10-15 for skin or UTI).
Oral for CDiff only
Corn allergy, nephrotoxic, ototoxic, thrombocytopenia

Question 17

Linezolid contraindicated with which class of drugs?

Answer 17

MAOIs
avoid high tyramine foods (cheese, meat, booze)
Don’t give with antidepressants = serotonin syndrome risk