HIV Flashcards

1
Q

NRTIs

A
Abacavir
Lamivudine
Emtricitabine (keep in original container)
Tenofovir
Zidovudine
Didanosine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

NNRTIs

A
Efavirenz (risk in 1st tri pregnancy) *no breastfeeding for HIV patients
Etravirine
Rilpivirine
Nevirapine (viramune)
(never monotherapy - causes resistance)
*most are CYP substrates
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

NRTI black box

A

lactic acidosis

severe hepatomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Zidovudine severe reaction

A

blood toxicity - neutropenia, severe anemia

myopathy with long term use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Didanosine severe reaction

A

Pancreatitis (could be fatal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Triumeq

A

Abacavir(NRTI) + Lamivudine(NRTI) + Dolutegravir(integrase)

*once daily, keep in original container

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Truvada

A

Emtricitabine(NRTI) + Tenofovir fumarate(NRTI)
1 daily with or without food
*watch renal toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Descovy

A

Emtricitabine(NRIT) + Tenofovir alafenamide(NRTI)
newer version of truvada - almost same SE
1 daily
*interacts w/ pglycoprotein. avoid anticonvulsants, rifampin, st johns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Stribild

A

Emtricitabine(NRTI) + Tenofovir fumarate(NRTI) + Elvitegravir/cobicistat
1 daily with food

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Epzicom

A

Lamivudine + Abacavir (both NRTIs)

1 daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Triumeq

A

Lamivudine + Abacavir/Dolutegravir

1 daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Didanosine interaction

A

Avoid allopurinol

avoid with tenofovir or reduce dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

NNRTI/Nevirapine Black Box

A
Hepatotoxicity
Skin reactions (SJS/TEN)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Atripla

A

Tenofovir(NRTI) + Emtricitabine(NRTI) + Efavirenz(NNRTI)

1 QHS empty stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Intelence

A

Etravirine (NNRTI)
SE: rash, liver increased enzymes
major CYP
200 mg BID with meals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which HIV meds can reduce contraceptive effectiveness?

A

Efavirenz
Nevirapine
Ritonavir

17
Q

Protease Inhibitors

A

-NAVIR meds
SE: lipodystrophy, buffalo hump/breast enlargement
-must give with booster
-Some have sulfa allergy and avoid PPIs
-most are CYP3A4 inhibitors(avoid anticoag)

18
Q

Reyataz

A

Atazanavir

take 2 hrs before or 1 hr after PPIs

19
Q

What are boosters?

A

Use with Protease Inhibitors
Ritonavir
Cobicistat

20
Q

Integrase Inhibitors (INSTI)

A

Isentress (Raltegravir)

Tivicay (Dolutegravir)

21
Q

Treatment naive Regimen pg.187

A

2 NRTIs + NNRTI(EER) or Protease(navir)/booster or INSTI

22
Q

Which HIV med is not PO?

A

Fuzeon(Enfuvirtide) - injection subQ Q12H for treatment-experienced

23
Q

Which HIV meds overlap with Hep B?

A

Emtricitabine, Lamivudine, Tenofovir

they can treat hepB, pts might have increased resistance

24
Q

Contraindicated with PPIs?

A

Rilpivirine

25
Q

HIV meds with food

A

Darunavir, Atazanavir, Rilpivirine

26
Q

HIV med without food

A

Efavirenz

27
Q

Which HIV med has sulfa?

A

Tipranavir

28
Q

Which HIV med requires high fat meal?

A

Elvitegravir

29
Q

The updated Tenofovir version reduces what SE?

A

Less Bone loss

Less Renal toxicity

30
Q

Which HIV med can increase INR (bleed risk with Warfarin)

A

NORVIR - CYP3A4 inhibitor

same with Gleevec, imatinib a TKI