HIV Flashcards
NRTIs
Abacavir Lamivudine Emtricitabine (keep in original container) Tenofovir Zidovudine Didanosine
NNRTIs
Efavirenz (risk in 1st tri pregnancy) *no breastfeeding for HIV patients Etravirine Rilpivirine Nevirapine (viramune) (never monotherapy - causes resistance) *most are CYP substrates
NRTI black box
lactic acidosis
severe hepatomegaly
Zidovudine severe reaction
blood toxicity - neutropenia, severe anemia
myopathy with long term use
Didanosine severe reaction
Pancreatitis (could be fatal)
Triumeq
Abacavir(NRTI) + Lamivudine(NRTI) + Dolutegravir(integrase)
*once daily, keep in original container
Truvada
Emtricitabine(NRTI) + Tenofovir fumarate(NRTI)
1 daily with or without food
*watch renal toxicity
Descovy
Emtricitabine(NRIT) + Tenofovir alafenamide(NRTI)
newer version of truvada - almost same SE
1 daily
*interacts w/ pglycoprotein. avoid anticonvulsants, rifampin, st johns
Stribild
Emtricitabine(NRTI) + Tenofovir fumarate(NRTI) + Elvitegravir/cobicistat
1 daily with food
Epzicom
Lamivudine + Abacavir (both NRTIs)
1 daily
Triumeq
Lamivudine + Abacavir/Dolutegravir
1 daily
Didanosine interaction
Avoid allopurinol
avoid with tenofovir or reduce dose
NNRTI/Nevirapine Black Box
Hepatotoxicity Skin reactions (SJS/TEN)
Atripla
Tenofovir(NRTI) + Emtricitabine(NRTI) + Efavirenz(NNRTI)
1 QHS empty stomach
Intelence
Etravirine (NNRTI)
SE: rash, liver increased enzymes
major CYP
200 mg BID with meals