Anticoag Flashcards
What can increase bleed risk when given with anticoagulants?
NSAIDs, SSRIs, fish oil, garlic, ginger, ginkgo, ginseng, glucosamine, willow, grapefruit
Heparin route of admin
IV or SubQ (NOT IM = hematoma)
Heparin SE
increased AST, thrombocytopenia/HIT, bleeding
Heparin antidote
Protamine
Enoxaparin dosing
generally 1 mg/kg
QD for prevention
BID for treatment
renal dosing: 30 mg qd
Enoxaparin antidote and monitoring
Protamine. Maybe monitor antiXa but not always req.
Warfarin full effect in how many days?
6 days
VItamin K effect on Warfarin
Vit K DECREASES Warfarin
decreases INR
When to avoid Warfarin?
HIT patients, with Amiodarone or NSAIDs, CYP2C9 genetic variation or CYP3A4 interactions
Warfarin antidote?
Vitamin K
Warfarin INR goals
2-3 for normal range
2.5-3.5 for mitral valve pts
Increased Bleed Risk with Warfarin
Amiodarone, Zafirlukast, Azoles, Bactrim, Macrolides(zpak), tetracycline, FQs, PCNs, etravirine
Drugs that decrease INR
Carbamazepine, Phenytoin, Phenobarb, Rifampin, Aprepitant, St Johns, Primidone, vit K
Black Box for Dabigatran or Bivlirudin
Epidural = hematoma = paralysis
Pradaxa generic
Dabigatran