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Harri 's Quick peak > Oncology > Flashcards

Oncology Flashcards

1
Q

Cancer incidence in both sex

A

Male: prostate>lung>colorectal>bladder
Female: breast>lung>colorectal>endometrial

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2
Q

Most prevalent cause of Cancer death for both sexes

A

Lung

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3
Q

Most significant risk factor for cancer

A

AGE

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4
Q

Second most common cancer

A

Breast

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5
Q

Diagnosis of cancer relies heavily on

A

Tissue biopsy

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6
Q

Curability of a tumor is usually inversely proportional to

A

Tumor burden

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7
Q

Cancer Staging based on PE, radiographs, isotopic scans, other imaging procedures

A

Clinical staging

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8
Q

Cancer staging based on information obtained during a surgical procedure( intrsoperative palpation, resection of regions lymph nodes and/ or +issue adjacent to the tumor, inspection and biopsy of Organs commonly involved in disease spread)

A

Pathologic Staging

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9
Q

most widely used staying System for Cancer

A

T N M ( tumor, node, metastasis) System

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10
Q

EC06 Grade For a patient capable only of limited self - care I confined to bed or chair more than 50% of waking hours

A

ECO6 Grade 3

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11
Q

Administration of chemotherapy or chemotherapy- radiation therapy BEFORE definitive surgery

A

Neoadjuvant therapy

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12
Q

most common sidereffects of Cancer Therapy

A

N and V, Febrile neutropenia, myelosuppression

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13
Q

> 50% reduction in the sum of the products of the perpendicular diamete rs of all measurable lesions
Based on RECIST:>/30% decrease in the suns of the longest diameters of lesions

A

Partial response

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14
Q

Appearance of any new lesion or an increase of> 25% in the Sum Of the products of the perpendicular diameters ok all measurable lesions
REG ST:> Or= 20% increase in the Sums of the longest diameter

A

progressive disease

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15
Q

Tumor marker For Gestational trophoblastic disease, gonadal germ tumor

A

HCG

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16
Q

Tumor marker for Hepatocellular CA, GonadsI germ cell tumor

A

Alpha Fetoprotein

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17
Q

CA - 125

A

Ovarian cancer, some lymphomas

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18
Q

CA 19-9

A

Pancreatic, Colon, Breast

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19
Q

CD 30

A

Hodgkin’s disease, anaplastic large cell lymphoma

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20
Q

C D 25

A

Hairy cell leukemia, Adult Tall leukemia/ lymphoma

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21
Q

most avoidable risk Factor for pulmonary, cardiovascular disease and cancer

A

Smoking Cessation

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22
Q

Cancers associated with smoking

A

Larynx, oropharynx, esophagus, kidney, bladder, pancreas stomach

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23
Q

Smoking cessation reduces lover lung cancer mortality by how much

A

30-50% compared to continued smoking

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24
Q

Decrease risk or colon and breast cancer

A

physical Activity

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25
Q

High Fat diet increases the risk for what cancer

A

Breast, colon, prostate, endometrium

26
Q

BMl> 25kglm2

A

Increases Cancer Risk

27
Q

induces non melanoma skin cancer (basal Cell And squamous cell)

A

Cumulative exposure to UV radiation

28
Q

Linked to melanoma

A

Intermittent acute sun exposures and sun damage

29
Q

Benefits of Sunscreens

A

Decrease the risk of actinic keratosis. precursor Of Squamous cell skin cancer

30
Q

Increases lung Cancer incidence and mortality

A

Beta carotene

31
Q

Most common causes Of SVC

A

malignant Tumors ( Lung cancer, lymphoma sand met astatic tumors)

32
Q

most common etiology of SVC in young adults

A

Malignant lymphoma

33
Q

Poor prognosticators for S V C

A

Cerebral and or laryngeal edema

34
Q

most significant CXR Finding in SVC

A

Widened superior mediastinum

may have concurrent right sided pleural effusion

35
Q

Provides the most reliable view of mediasfinal anatomy in SVC

A

chest CT scan

36
Q

Life threatening complication of s V C

A

Tracheal Obstruction

37
Q

Role of glucocorticoids in lymphoma

A

Only in Lymphoma but no benefit if with Lung LA

38
Q

Primary tvestment For SVC

A

Radiotherapy

39
Q

Most Frequent cancer etiologies associated with pericardial effusion

A

Thoracic malignancies: lung, breast, Lymphomas, Leukemia

40
Q

Most helpful diagnostic test for patients with pericardial effusion associated cwith malignancy

A

2D echo

41
Q

Best diagnostic yield For pericardial effusion in cancer patients

A

Cytology + pericardial and epicardial biopsy+ guided pericardioscopy

42
Q

pericardial Fluid with malignant cells on cytology has

A

Poor survival at 7 weeks

43
Q

Recurrence rate of pericardial effusion in cancer patients

A

20% reduced with sclerotherapy( bleomycin, mitomycin C tetracycline)

44
Q

complication of drainage of pericardial effusion

A

post operative low cardiac output syndrome

45
Q

most common Cause of MSCC

A

Lung Cancer

46
Q

Most common site of MSCC

A

Thoracic spine ( 70% )

47
Q

Tingling or electric sensation down the back and limbs upon neck Flexion or extension

A

Lhermitte’s sign

48
Q

Earliest radiologic finding of vertebral tumor

A

Erosion of the pedicles ( winking owl sign)

49
Q

Imaging procedure of choice for MSCC

A

MRI

50
Q

Initial Treatment of Choice for MSCC

A

Radiation therapy+glucocorticoid ( Dexa)

51
Q

Most common cancer etiologics For Intestinal Obstruction

A

Colorectal, Ovarian

52
Q

Most common cause of small bowel obstruction in cancer patients

A

Melanoma

53
Q

Due to Infiltration of the mesentery or bowel muscle by tumor involvement of celiac plexus, or paraneoplastic neuropathy( SCLC)

A

intestinal bsendoobstruction

54
Q

IgG antibodies reactive to neurons of the myenteric and submucosal plexuses of the jejunum and stomach

A

Paraneoplastic neuropathy

55
Q

Most common metastatic tumors causing biliary obstruction

A

Gastric, colon, breast, lung cancers

56
Q

persistent hypoglycemia in cancer patients

A

Pancreatic islet Cell tumors, tumors Of mesenchymal origin, hepatomas, or adrenocortical tumors

57
Q

Features of Tumor Lysis Syndrome

A

Hyperuricemia, Kalemia, phosphatemia

Hypocalcemia

58
Q

Drugs associated with HUS - TTP

A

Mitomycin, gemcitabine, cisplatin, bleomYcin, VEGF inhibitors

59
Q

HUS as a complication usually occurs how many weeks after chemo

A

4-8

60
Q

Features of HUS

A

microangiopathic hemolytic anemia, thrombocytopenia, renal failure

61
Q

Chemo drugs associated with hemorrhagic cystitis

A

Cyclophosphamide or ifosfamide

62
Q

Treatment for chemo induced hemorrhagic cystitis

A

MESNA

Harri 's Quick peak (10 decks)

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