Oncology Flashcards

1
Q

Cancer incidence in both sex

A

Male: prostate>lung>colorectal>bladder
Female: breast>lung>colorectal>endometrial

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2
Q

Most prevalent cause of Cancer death for both sexes

A

Lung

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3
Q

Most significant risk factor for cancer

A

AGE

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4
Q

Second most common cancer

A

Breast

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5
Q

Diagnosis of cancer relies heavily on

A

Tissue biopsy

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6
Q

Curability of a tumor is usually inversely proportional to

A

Tumor burden

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7
Q

Cancer Staging based on PE, radiographs, isotopic scans, other imaging procedures

A

Clinical staging

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8
Q

Cancer staging based on information obtained during a surgical procedure( intrsoperative palpation, resection of regions lymph nodes and/ or +issue adjacent to the tumor, inspection and biopsy of Organs commonly involved in disease spread)

A

Pathologic Staging

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9
Q

most widely used staying System for Cancer

A

T N M ( tumor, node, metastasis) System

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10
Q

EC06 Grade For a patient capable only of limited self - care I confined to bed or chair more than 50% of waking hours

A

ECO6 Grade 3

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11
Q

Administration of chemotherapy or chemotherapy- radiation therapy BEFORE definitive surgery

A

Neoadjuvant therapy

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12
Q

most common sidereffects of Cancer Therapy

A

N and V, Febrile neutropenia, myelosuppression

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13
Q

> 50% reduction in the sum of the products of the perpendicular diamete rs of all measurable lesions
Based on RECIST:>/30% decrease in the suns of the longest diameters of lesions

A

Partial response

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14
Q

Appearance of any new lesion or an increase of> 25% in the Sum Of the products of the perpendicular diameters ok all measurable lesions
REG ST:> Or= 20% increase in the Sums of the longest diameter

A

progressive disease

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15
Q

Tumor marker For Gestational trophoblastic disease, gonadal germ tumor

A

HCG

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16
Q

Tumor marker for Hepatocellular CA, GonadsI germ cell tumor

A

Alpha Fetoprotein

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17
Q

CA - 125

A

Ovarian cancer, some lymphomas

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18
Q

CA 19-9

A

Pancreatic, Colon, Breast

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19
Q

CD 30

A

Hodgkin’s disease, anaplastic large cell lymphoma

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20
Q

C D 25

A

Hairy cell leukemia, Adult Tall leukemia/ lymphoma

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21
Q

most avoidable risk Factor for pulmonary, cardiovascular disease and cancer

A

Smoking Cessation

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22
Q

Cancers associated with smoking

A

Larynx, oropharynx, esophagus, kidney, bladder, pancreas stomach

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23
Q

Smoking cessation reduces lover lung cancer mortality by how much

A

30-50% compared to continued smoking

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24
Q

Decrease risk or colon and breast cancer

A

physical Activity

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25
High Fat diet increases the risk for what cancer
Breast, colon, prostate, endometrium
26
BMl> 25kglm2
Increases Cancer Risk
27
induces non melanoma skin cancer (basal Cell And squamous cell)
Cumulative exposure to UV radiation
28
Linked to melanoma
Intermittent acute sun exposures and sun damage
29
Benefits of Sunscreens
Decrease the risk of actinic keratosis. precursor Of Squamous cell skin cancer
30
Increases lung Cancer incidence and mortality
Beta carotene
31
Most common causes Of SVC
malignant Tumors ( Lung cancer, lymphoma sand met astatic tumors)
32
most common etiology of SVC in young adults
Malignant lymphoma
33
Poor prognosticators for S V C
Cerebral and or laryngeal edema
34
most significant CXR Finding in SVC
Widened superior mediastinum | may have concurrent right sided pleural effusion
35
Provides the most reliable view of mediasfinal anatomy in SVC
chest CT scan
36
Life threatening complication of s V C
Tracheal Obstruction
37
Role of glucocorticoids in lymphoma
Only in Lymphoma but no benefit if with Lung LA
38
Primary tvestment For SVC
Radiotherapy
39
Most Frequent cancer etiologies associated with pericardial effusion
Thoracic malignancies: lung, breast, Lymphomas, Leukemia
40
Most helpful diagnostic test for patients with pericardial effusion associated cwith malignancy
2D echo
41
Best diagnostic yield For pericardial effusion in cancer patients
Cytology + pericardial and epicardial biopsy+ guided pericardioscopy
42
pericardial Fluid with malignant cells on cytology has
Poor survival at 7 weeks
43
Recurrence rate of pericardial effusion in cancer patients
20% reduced with sclerotherapy( bleomycin, mitomycin C tetracycline)
44
complication of drainage of pericardial effusion
post operative low cardiac output syndrome
45
most common Cause of MSCC
Lung Cancer
46
Most common site of MSCC
Thoracic spine ( 70% )
47
Tingling or electric sensation down the back and limbs upon neck Flexion or extension
Lhermitte's sign
48
Earliest radiologic finding of vertebral tumor
Erosion of the pedicles ( winking owl sign)
49
Imaging procedure of choice for MSCC
MRI
50
Initial Treatment of Choice for MSCC
Radiation therapy+glucocorticoid ( Dexa)
51
Most common cancer etiologics For Intestinal Obstruction
Colorectal, Ovarian
52
Most common cause of small bowel obstruction in cancer patients
Melanoma
53
Due to Infiltration of the mesentery or bowel muscle by tumor involvement of celiac plexus, or paraneoplastic neuropathy( SCLC)
intestinal bsendoobstruction
54
IgG antibodies reactive to neurons of the myenteric and submucosal plexuses of the jejunum and stomach
Paraneoplastic neuropathy
55
Most common metastatic tumors causing biliary obstruction
Gastric, colon, breast, lung cancers
56
persistent hypoglycemia in cancer patients
Pancreatic islet Cell tumors, tumors Of mesenchymal origin, hepatomas, or adrenocortical tumors
57
Features of Tumor Lysis Syndrome
Hyperuricemia, Kalemia, phosphatemia | Hypocalcemia
58
Drugs associated with HUS - TTP
Mitomycin, gemcitabine, cisplatin, bleomYcin, VEGF inhibitors
59
HUS as a complication usually occurs how many weeks after chemo
4-8
60
Features of HUS
microangiopathic hemolytic anemia, thrombocytopenia, renal failure
61
Chemo drugs associated with hemorrhagic cystitis
Cyclophosphamide or ifosfamide
62
Treatment for chemo induced hemorrhagic cystitis
MESNA