HEMA

Question 1

Most common anemia

Answer 1

Hypoproliferative

Question 2

Normocytic and Normochromic RBC with inappropriately low retic response( <2 -2.5)

Answer 2

Hypoproliferative anemia

Question 3

Most common Hypoproliferative anemia

Answer 3

early IDA

Question 4

Mechanism Of Hypo proliferative anemia

Answer 4

1. Abnormal iron metabolism: IDA, anemia of inflammation

2. Suboptimal erythropoietin response to anemia: renal disease, inflammation, cancer, hypometabolic states

Question 5

Determines the turnover ra+e of transferrin iron

Answer 5

Plasma iron level and the activity of the erythroid marrow

Question 6

Conditions associated with decreased clearance time of transferrin iron
(inc clearance /fast turnover)

Answer 6

Increased erythropoieSis

IDA

Question 7

Average RBC lifespan

Answer 7

120 days

Question 8

One ml Of RBC is equal to how many mg of Iron

Answer 8

One

Question 9

Amount Of iron needed to replace the RBC lost through senescence

Answer 9

20 mg/ day

Question 10

For pregnant women on their last- two trimesters, how much iron is required per day

Answer 10

increased to 5-6 mg /d

Question 11

Primary location for iron absorption

Answer 11

proximal small intestine

Question 12

principal iron regulator hormone

Answer 12

HepCidin

Question 13

Increased iron absorption despite normal or inc iren stores with associated inappropriately Low hepcidin

Answer 13

Erythroid hyperplasia

Question 14

Indicators Of decreased iron stores

Answer 14

Decreased Serum Ferritin

Decreased stainable iron on bone marrow aspirations

Question 15

Represents the amount Of Circulating iron bound to transferrin

Answer 15

Serum iron ( NV: 50 to 150)

Question 16

Indirect measure of circulating transferrin

Answer 16

TIBC (NV: 300 to 360)

Question 17

TSAT in iron deficiency States

Answer 17

<18%

Question 18

Test to estimate iron stores

Answer 18

Serum Ferritin level

Question 19

Most common causes Of increased Red cell protoporphyrin levels

Answer 19

IDA, lead poisoning

Question 20

Reflects the total erythroid mass and can distinguish between IDA and anemia of inflammation

Answer 20

transferrin Receptor protein

Question 21

In absolute IDA TRP is

Answer 21

Elevated

Question 22

Conditions that present with hypochromic microcystic anemia

Answer 22

Thalassemias
Anemia of inflammation with inadequate iron supply to the erythroid marrow
MDS

Question 23

Max dose of elemental iron per day

Answer 23

200

Question 24

Inhibits iron absorption and release from storage sites

Answer 24

Hepcidin

Question 25

Known as Unpaired globin precipitates to form inclusions that damage the cell

Answer 25

Heinz bodies

Question 26

When is reticulOcyte count expected to increase after iron therapy

Answer 26

4-7 dayswith peak rise 1-1.5 weeks

Question 27

Most prominent SE of iron therapy

Answer 27

GI distress in 15-20% of Pxs

Question 28

Categories in Hypoproliferative anemias with inadequate endogenous EPO production for the degree of anemia observed

Answer 28

l. Chronic inflammation/ infection
2. Renal disease
3. Endo and nutritional deficiencies

Question 29

Goals for the tx of anemia

Answer 29

NO intervention until hgb <8(if wo serious underlying CV/ Pulmo disease
> 11g/dl if with physiologic compromise

Question 30

AE Of Epo administration in cancer patients

Answer 30

Increased risk of thromboembolic complications and tumor progression

Question 31

Mutation in the Beta- globin gene due to change of 6th aminoacid from glutamic acid to valine

Answer 31

sickle cell