GASTRO Flashcards
Storage function, relaxes to accomodate the meal
Proximal stomach
Phasic contractions, propels food residue against the pylorus
Distal stomach
secretes intrinsic Factor for Vitamin B12 absorption
Stomach
Suited For absorption of vit B 12 and bile acids
Ileum
GI diseases with impaired digestion and Absorption
ZE, lactase deficiency, Biliary obstruction, other intestinal enzyme deficiencies
most common intestinal maldigestion syndrome involving dairy products ( lactose content)
L actase deficiency
GI diseases with altered secretion
Gastric acid hypersecretion: ZE, G-cell hyperplasia, retained antrum Syndrome, some with DU
Gastric acid hyposecretion: Atrophic gastritis, pernicious anemia
Inflammation and infection
GI diseases with altered Gut Transit
mechanical Obstruction
Disordered Gut motor Function: impaired propulsion/ rapidpropulsion disorders
GI diseases associated with immune dysregulation
Celiac disease, Eosinophilic gastritis, Ulcerative colitis and Chron’s disease
GI diseases with Impaired Gut Blood flow
Thromboembolic causes: arterial embolus or thrombosis, venous thrombosis
Hypoperfusion causes: dehydration, sepsis, hemorrhage or decreased CO
Radiation enterocolitis
Gastroparesis due to blockage of the celias and SMA
GI disease typically presenting at after age 50
Colorectal CA
may be due to chronic acid reflux or with extensive Alcohol and tobacco use
Esophageal cancer
Abdominal pain:generally midline in location and vague in character
visceraL pain
Abdominal pain that can be localized and precisely described
Parietal pain
Most common causes of abdominaL pain
IBS and Functional dyspepsia
Initial procedure to evaluate dysphagia to exclude subtle rings or strictures and assess for achalasia
Barium swallow
Performed when colonoscopy is unsuccessful or contraindicated
Contrast enema
Alternative for colonoscopy For colon cancer screening
CT and MR Colongraphy
Diagnostic modality used to exclude mesenteric ischemia and determines Spread of malignancy
Angiography
Userful in searching for Intraabdominal abscesses not visualized on CT
Radio labeled leukocyte scans
Esophageal manometry is a functional test used for patient’s suspected Of
Achalasia
GOld standard for imaging of colonic mucosa
Colonoscopy
More accurate for evaluation of diverticula and measurement of colonic strictures
Barium enema
Procedure used to visualize the rectum and a variable portion of the left colon
used for colorectal cancer screening primarily used for evaluation of diarrhea and rectal outlet bleeding
Flexible Sigmoidoscopy
Used as both diagnostic and therapeutic procedure
open sphincter of Oddi: endoscopic sphincterotomy
Retrieval of stones from the ducts
Biopsy, dilation and stenting of duct strictures, stenting of ductal leaks
Di agnosis: sphincter of Oddi dysfunction
ERCP
Most accurate pre - op local staging of Cancers
EUS
Risks of Bleeding and GI perforation
Low risk: Diagnostic Upper endoscopy, Colonoscopy, diagnostic Eus
Increased risk: Therapeutic procedures such as EMR and ESD, control of bleeding, or Stricture
Rare with flexible sigmoidoscopy
Recommended to Start Antibiotic prophylaxis For Endoscopic procedure
Bile duct obstruction (-) Cholangitis: ERCP with anticipated incomplete drainage: prevention of Cholangitis
Sterile Pancreatic fluid collection (pseudooyst, necrosis) which communicates with pancreatic duCt: ERCP: cyst infection
Sterile pancreatic Fluid collection: Transmural drainage: cyst infection
cystic lesions along GI tract: EUS- FNA: cyst infection
percutaneous Endoscopic feeding tube placement: periostomal infection
Cirrhosis with acute GI bleeding: All patients regardless of endoscopic procedure
LR endoscopic procedures for the management of Antithrombotic Drugs before Endoscopy
EGD or colonoscopy with/ without Biopsy, EUS without FNA, ERCP with stent exchange
HR endoscopic procedures for the management of Antithrombotic Drugs before Endoscopy
E G D or colonoscopy with dilation, Polypectomy or thermal ablation, PEG, Eus with FNA, ERCP with sphincterotony or psendocyst drainage
Antithrombotic drug that does not increase the risk of bleeding during endoscopic procedures
Aspirin monotherapy
Risk of developing Pancreatitis during ERCP
5% with increased risk in young anicteric patients with normal ducts
Most common complication in Percutaneous gastrostomy tube placement during EGD
Wound infection
Increases likelihood of rebleeding from endoscopy
R/R-A-C/C
Respi/Renal Failure
Age> 70 y 0.
Cirrhosis/ Coagulopathy
Indications for urgent endoscopy
Resting hypotension, repeated hematemesis, Ngt aspirate that does not clear with large volume lavage, orthostatic change in vital signs, or requirement for BT
PUD risk of rebleeding: clean- based ulcer
low risk (3-5 %)
PUD risk of rebleeding:
Flat red or purple spots in the ulcer base
Large adherent CLots covering the ulcer base
Intermediate risk
10% and 20%
PUD risk of rebleeding: sentinel clot ( platelet plug protruding from a vessel wall in the base of an ulcer) or visible vessel; often requires local endoscopic therapy to decrease the bleeding rate
High Risk: approximately 40%
Reduces Rebleeding rate and improves patient outcome
proton Pump Inhibitor
Indicated for primary prophylaxis from large esophageal varices when BBS are. contraindicated or not tolerated preferred last therapy For bleeding esophageal varices and eradication of varices
Endoscopic Variceal Ligation
Used as salvage therapy when EVL Fails as it has higher complication rates
Endoscopic variceal sclerotherapy
Persistent caliber artery
Large caliber arteriole that runs immediately beneath the GI mucosa and bleeds through a pinpoint mucosal erosion
Dieulafoy’s Lesion
Most common location Of the Dieulafoy’s lesion
Lesser curvature of the proximal stomach
Linear mucosal rent near or across the GE junction often associated with retching or vomiting
Mallory- Weiss tear
Watermelon stomach
Gastric antral Vascular Ecasias (GAVE)
Flat mucosal anomalies diagnosed by endoscopy
vascular Ectasias
Etiology of bleeding: nutrient arteries penatrating the muscular wall of the colon en route to the colonic mucosa
Characterized by painless and impressive hermatOchezia
Colonic Diverticula
Common Causes of G00
malignancy and Chronic peptic ulceration with stenosis of the by pylorus
Risk of cecal perforation
> 12 cm
More accurate disqustic modality for Bile buct imaging
Mrcp and Eus >90 % accuracy
Procedure of choice if a bile duct stone is highly likely and urgent treatment is required(jaundice and biliary sepsis)
ERCP
Procedure of choice if a bile duct stone is highly likely and urgent treatment is required(jaundice and biliary sepsis)
ERCP
Charcot ‘s triad
Jaundice, fever, RUQ pain
Reynold’s Pentad
Charcot ‘s triad+ confusion and shock
Most sensitive test for diagnosis Of GERD
24 H ambulatory pH monitoring
Indications For endoscopy in GERD
Resistant reflux symptoms
Recurrent dyspepsia
Reflux and dysphagia to look for a stricture or malignancy
Long standing (more than or equal to 10 years) Frequent heartburn due to 6x increase risk of Barrett’s esophagus(periodic endoscopy with biopsy) to detect dysplasia or early carcinoma
Most sensitive diagnostic test For Peptic ulcer
Endoscopy
Alarm symptoms for endoscopy in Peptic ulcer
Weight loss, Anemia, Bleeding
progressive dysphagia, solids then liquids
Esophageal strictures
Intermittent dysphagia For both solids and liquids
Motor disorders
Episodic dysphagia For solids, typically at the beginning of a meal
Schatzki’s ring
Difficultly initiating deglutition ( transfer dysphagia) and nasal reflux with swallowing
pharyngeal motor disorders
Nocturnal regurgitation of undigested Food
Achalasia
Best initial test if motor disorder is suspected in dysphagia
Esophageal radiography and or a video Swallow study
Procedure done For resection of early-stage malignancies limited to the superficial layers of the GI mucosa
EMR or ESD
Colorectal Cancer screening strategies:
Asymptomatic individuals more than Or equal to 50 y. 0.
FOBT annually
CT colonography/ Flexible sigmoidoscopy /Double contrast barium enema every 5 years
Colonoscopy every 10 years
Chronic diarrhea ( Duration)
4 weeks
Behavior in which recently swallowed Food is regurgitated and then re swallowed repetitively for up to an hour
Rumination
Globus sensation is attributable to What disease
GERD
Useful test for diagnosing motility disorders. achalasia, diffuse esophageal spasm
Esophageal manometery
Outpouchings Of the esophagus wall, associated with increased intraluminal pressure associated with a distal obstruction
Diverticula
Seen in natural zone of weakness in the posterior hypopharyngeal wall (Killian’s triangle) and causes halitosis and regurgitation of saliva and food that may have been consumed several days earlier
Zenker’s diverticulum
Due to traction from adjacent inflammation ( tuberculosis) or by propulsion associated with esopageal motor abnormalities
midesophageal diverticulum
Thin membranous narrowing at the squamocolumnar mucosal junction Of the esophagus, seen in 10-15% of the population usually asymptomatic
B-ring
Similar to B - ring but with a lumen diameter of 13 mm and associated with episodic solid food dysphagia
Schatzki’s ring
Steakhouse Syndrome
Schatzki’s ring
Symptomatic hypopharyngeal webs and iron- deficiency anemia in middle -aged women
plummer - Vinson syndrome
Herniation of part of the stomach into the thoracic Cavity through the esophageal hiatus in the diaphragm
Hiatal hernia
Type of hiatal hernia which is associated with GERD
Type I sliding hiatal hernia (95% cases)
Esophageal CA with predilection to the distql esophagus
Adenocarcinoma
Esophageal cancer with predilection to the proximal esophagus
SCC
Rare motor disorder of the esophageal smooth muscle in which the LES does not relax normally with swallowing and the esophageal body undergoes non-peristaltic contractions
Achalasia
Loss of ganglion cells within the esophageal myenteric plexus involving both excitatory ( Cholinergic) and inhibitory(nitric oxide) ganglionic neurons
Achalasia
ManOmeric finding of the esophageal LES in patients with Achalasia
Normal or elevated pressure
Barium swallow xray Finding of patients with Achalasia
Dilated esophagus with poor emptying, air fluid level, tapering at the LES beak like appearance
Pharmacologic therapy For patients with Achalasia
Nitrates or CCB before meals
Botulinum toxin
Manifests as episodes of dysphagia with chest pain attributable to abnormal esophageal contractions with normal deglutitive LES relaxation
Diffuse Esophageal Spasm
Corkscrew esophagus
Rosary bead esophagus
psendo diverticula or curling
DES