Oncology Flashcards
Which is an example of a
paraneoplastic syndrome?
A. Peripheral neuropathy due to vincristine B. Microcytic hypochromic anemia in a cat from intestinal MCT C. Microcytic hypochromic anemia in a dog due to dermal MCT D. Thrombocytopenia due to a splenic hemangiosarcoma
C. Microcytic hypochromic
anemia in a dog due to
dermal MCT
What is a side‐effect of
cyclophosphamide therapy caused by
acrolein?
A. Vesicant B. Sterile hemorrhagic cystitis C. Gastrointestinal toxicity D. Neurotoxicity
A. Vesicant
What method of administration is not
associated with reduced risk of this
toxicity
A. Divided doses orally over three days B. Administration of Mesna at the same time as intravenous drug C. Administration of Furosemide prior to Cyclophosphamide D. Giving the drug at night E. Salty snacks to encourage drinking
D. Giving the drug at night
Joey comes to your clinic for a 7 day follow‐up check
post‐cyclophosphamide (CHOP). He is due to receive
vincristine. His neutrophil count is 1200 cells/μL
(1.2.109/L RI: >3.109/L). What do you suggest to Joey’s
owner?
A. Give the vincristine, but at a 25% reduced dose B. Substitute with a nonmyelotoxic drug C. Postpone chemotherapy for 7 days and prescribe antibiotics (TMS) D. Stop chemotherapy altogether
C. Postpone chemotherapy
for 7 days and prescribe
antibiotics (TMS)
Joey comes to your clinic for a 7 day follow‐up check
post‐doxorubicin (CHOP). His neutrophil count is 300
cells/μL (0.3.109/L). Joey has a fever. What do you
suggest to Joey’s owner?
A. Recommend repeat sampling in 7 days to see if he has recovered from his nadir B. Substitute doxorubicin the future with dactinomycin C. Send Joey home with TMS course of antibiotics D. Admit Joey to the isolation facility and start with broad spectrum Abx
D. Admit Joey to the isolation
facility and start with broad
spectrum Abx
A dog receives 6 Gy of radiation weekly for 4
weeks, weekly, before chemotherapy for an
osteosarcoma. There is no amputation. Describe
the type of radiation course?
A. Definitive, hypofractionated, adjuvant B. Definitive, hyperfractionated, adjuvant C. Palliative, hypofractionated, neoadjuvant D. Palliative, hyperfractionated, adjuvant
C. Palliative, hypofractionated,
neoadjuvant
You recheck a Pug you referred for radiation therapy (LINAC)
for a muzzle MCT after the second week. What is the correct
assessment?
A. The dramatic response is a good sign B. Too early to make a decision, the tumor may recur C. This is a highly aggressive tumor and carries a grave prognosis D. The cancer is cured, go home Pug
B. Too early to make a
decision, the tumor may
recur
Joey has peripheral lymphadenopathy with a T‐cell lymphoma
but is otherwise healthy. Lymphoma cells are found in his spleen
and liver with FNA but not in the bone marrow. Classify his
lymphoma
A. Multicentric, T cell, stage IV, substage a B. Multicentric, T cell, stage V, substage a C. Multicentric, T cell, stage IV, substage b D. Extranodal lymphoma E. Acute lymphocytic leukemia
A. Multicentric, T cell, stage
IV, substage a
When we consider Joey’s lymphoma. Which is a
negative prognosticator?
A. Stage B. Location (multicentric) C. Immunophenotype (T cell) D. Grade
C. Immunophenotype (T
cell)
What treatment would you
recommend for Joey if the owner
elects curative intent?
A. Prednisolone B. Single agent CCNU C. Single agent doxorubicin D. Multi‐agent COP E. Current CHOP (19‐ week protocol)
E. Current CHOP (19‐
week protocol)
What is the estimated RR and
remission time if we treated Joey with
a 19‐week protocol
A. 30%, 3 months
B. 60%, 6 months
C. 80%, 12 months
D. 90%, 2 years
C. 80%, 12 months
Joey relapses in the middle of his 19‐
week CHOP protocol. What do you
recommend?
A. Reinduce with CHOP, week1 B. CCNU C. Prednisilone D. Euthenize
A. Reinduce with
CHOP, week1
Joey went into remission 1 month after starting CHOP,
completed his 19‐week protocol, 6‐months later he
relapsed. What rescue protocol would you use, and
what is the expected RR and remission time?
A. Doxorubicin, 70‐90% RR, remission of 7‐9 months B. Cyclophosphamide and Prednisolone combo, 60% RR, 3 months remission C. CCNU (Lomustine) or LOPP, 40% RR, 5 months remission time
C. CCNU (Lomustine) or
LOPP, 40% RR, 5 months
remission time
Which is correct regarding feline
intestinal lymphoma?
A. The most common form is high grade, lymphoblastic B. Mostly FeLV positive C. Young Siamese are predisposed D. Characterized by diffuse thickening of the muscularis propria on ultrasonography
D. Characterized by diffuse thickening of the muscularis propria on ultrasonography
What is not a clinical complication of a
multiple myeloma?
A. CVA B. Retinal detachment C. CKD D. Hypertrophic cardiomyopathy E. Hypercalcemia F. Thromboembolism
F. Thromboembolism
Joey, 6 yo, MN Golden retriever is diagnosed with an
osteosarcoma. The owner wants curative intent. What
are your treatment recommendations?
A. Start him on chemotherapy only B. Amputate the limb or limb sparing surgery C. Amputation/limb sparing + chemotherapy combination D. Radiation therapy of the sarcoma‐stereotactic “gamma knife” E. Pain killers including bisphosphonates– it is a poor prognosis
C. Amputation/limb sparing +
chemotherapy combination
f the standard of care is recommended to treat an
osteosarcoma (curative intent), what is the expected cure rate
(2 year survival)
A. 0‐5%
B. 5‐10%
C. 15‐25%
D. 30‐40%
C. 15‐25%
What is not a prognosticator for OSA in
a dog?
A. Age, > 7 year is worse B. Location, proximal humerus is worse C. ALKP, failure to decline to normal by D40 is worse D. Metastasis, presence has a shorter MST
A. Age, > 7 year is worse
‘Petal’ the 12 yo FN Siamese presents with a
mammary mass. What is the first thing you
recommend?
A. FNA B. Biopsy C. Radical bilateral, staged mastectomy D. Three thoracic radiographs E. Coagulation profile
D. Three thoracic
radiographs
Petal’s MGT: single, left cranial thoracic MG
mass, 4.7 cm diameter, LNN normal size. What is
the correct negative prognosticator?
A. Size: > 4 cm‐bad B. Tumor type: sarcoma vs carcinoma C. MG location: thoracic good D. Only one mass‐good E. N0‐good
A. Size: > 4 cm‐bad
Pilot, 14 yr, MN, Chow presents with an ulcerated,
swollen mass on his muzzle. FNA confirms it is a MCT.
The owner has very limited funds. What is the best
option for him?
A. Curative intent – surgery, radiation and vinblastine/CCNU B. TKI ‐ toceranib C. Palliative steroid therapy with H1 and H2 blockers D. NSAID and tramadol E. Doxorubicin single agent chemotherapy
C. Palliative steroid therapy
with H1 and H2 blockers
Pilot’s owner one day later decides that she would like to
proceed with definitive treatment for the MCT. The grade is
Patnaik III, or grade II on the 2‐tiered system, c‐kit PCR positive.
What Rx do you recommend after staging?
A. Radiation: LINAC B. Chemotherapy: CCNU & vinblastine C. Chemotherapy: Masivet D. Surgery/Radiation for loco‐regional control & chemotherapy for distant (L and M) and long‐term masivet
D. Surgery/Radiation for loco‐regional control & chemotherapy for distant (L and M) and long‐term masivet
What is a specific hematological
feature of hemangiosarcoma?
A. Anemia B. Heinz bodies C. Schistocytes D. Spherocytes E. Hypochromic RBC
C. Schistocytes
What is the expected MST in a dog that has had a
splenectomy for hemoabdomen but no follow‐up
chemotherapy?
A. 3 w – 3 m
B. 3 m‐ 6 m
C. 6 m – 12 m
D. 2 years
A. 3 w – 3 m
