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RUSVM Small Animal Medicine 2- A > Oncology > Flashcards

Oncology Flashcards

1
Q

Which is an example of a
paraneoplastic syndrome?

A. Peripheral neuropathy
due to vincristine
B. Microcytic hypochromic
anemia in a cat from
intestinal MCT
C. Microcytic hypochromic
anemia in a dog due to
dermal MCT
D. Thrombocytopenia due
to a splenic
hemangiosarcoma
A

C. Microcytic hypochromic
anemia in a dog due to
dermal MCT

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2
Q

What is a side‐effect of
cyclophosphamide therapy caused by
acrolein?

A. Vesicant
B. Sterile hemorrhagic
cystitis
C. Gastrointestinal
toxicity
D. Neurotoxicity
A

A. Vesicant

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3
Q

What method of administration is not
associated with reduced risk of this
toxicity

A. Divided doses orally
over three days
B. Administration of
Mesna at the same time
as intravenous drug
C. Administration of
Furosemide prior to
Cyclophosphamide
D. Giving the drug at night
E. Salty snacks to
encourage drinking
A

D. Giving the drug at night

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4
Q

Joey comes to your clinic for a 7 day follow‐up check
post‐cyclophosphamide (CHOP). He is due to receive
vincristine. His neutrophil count is 1200 cells/μL
(1.2.109/L RI: >3.109/L). What do you suggest to Joey’s
owner?

A. Give the vincristine, but at
a 25% reduced dose
B. Substitute with a nonmyelotoxic
drug
C. Postpone chemotherapy
for 7 days and prescribe
antibiotics (TMS)
D. Stop chemotherapy
altogether
A

C. Postpone chemotherapy
for 7 days and prescribe
antibiotics (TMS)

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5
Q

Joey comes to your clinic for a 7 day follow‐up check
post‐doxorubicin (CHOP). His neutrophil count is 300
cells/μL (0.3.109/L). Joey has a fever. What do you
suggest to Joey’s owner?

A. Recommend repeat sampling
in 7 days to see if he has
recovered from his nadir
B. Substitute doxorubicin the
future with dactinomycin
C. Send Joey home with TMS
course of antibiotics
D. Admit Joey to the isolation
facility and start with broad
spectrum Abx
A

D. Admit Joey to the isolation
facility and start with broad
spectrum Abx

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6
Q

A dog receives 6 Gy of radiation weekly for 4
weeks, weekly, before chemotherapy for an
osteosarcoma. There is no amputation. Describe
the type of radiation course?

A. Definitive, hypofractionated,
adjuvant
B. Definitive, hyperfractionated,
adjuvant
C. Palliative, hypofractionated,
neoadjuvant
D. Palliative, hyperfractionated,
adjuvant
A

C. Palliative, hypofractionated,

neoadjuvant

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7
Q

You recheck a Pug you referred for radiation therapy (LINAC)
for a muzzle MCT after the second week. What is the correct
assessment?

A. The dramatic response
is a good sign
B. Too early to make a
decision, the tumor may
recur
C. This is a highly
aggressive tumor and
carries a grave
prognosis
D. The cancer is cured, go
home Pug
A

B. Too early to make a
decision, the tumor may
recur

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8
Q

Joey has peripheral lymphadenopathy with a T‐cell lymphoma
but is otherwise healthy. Lymphoma cells are found in his spleen
and liver with FNA but not in the bone marrow. Classify his
lymphoma

A. Multicentric, T cell, stage
IV, substage a
B. Multicentric, T cell, stage
V, substage a
C. Multicentric, T cell, stage
IV, substage b
D. Extranodal lymphoma
E. Acute lymphocytic
leukemia
A

A. Multicentric, T cell, stage

IV, substage a

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9
Q

When we consider Joey’s lymphoma. Which is a
negative prognosticator?

A. Stage
B. Location (multicentric)
C. Immunophenotype (T
cell)
D. Grade
A

C. Immunophenotype (T

cell)

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10
Q

What treatment would you
recommend for Joey if the owner
elects curative intent?

A. Prednisolone
B. Single agent CCNU
C. Single agent
doxorubicin
D. Multi‐agent COP
E. Current CHOP (19‐
week protocol)
A

E. Current CHOP (19‐

week protocol)

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11
Q

What is the estimated RR and
remission time if we treated Joey with
a 19‐week protocol

A. 30%, 3 months
B. 60%, 6 months
C. 80%, 12 months
D. 90%, 2 years

A

C. 80%, 12 months

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12
Q

Joey relapses in the middle of his 19‐
week CHOP protocol. What do you
recommend?

A. Reinduce with
CHOP, week1
B. CCNU
C. Prednisilone
D. Euthenize
A

A. Reinduce with

CHOP, week1

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13
Q

Joey went into remission 1 month after starting CHOP,
completed his 19‐week protocol, 6‐months later he
relapsed. What rescue protocol would you use, and
what is the expected RR and remission time?

A. Doxorubicin, 70‐90% RR,
remission of 7‐9 months
B. Cyclophosphamide and
Prednisolone combo,
60% RR, 3 months
remission
C. CCNU (Lomustine) or
LOPP, 40% RR, 5 months
remission time
A

C. CCNU (Lomustine) or
LOPP, 40% RR, 5 months
remission time

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14
Q

Which is correct regarding feline
intestinal lymphoma?

A. The most common
form is high grade,
lymphoblastic
B. Mostly FeLV positive
C. Young Siamese are
predisposed
D. Characterized by
diffuse thickening of
the muscularis
propria on
ultrasonography
A 
D. Characterized by
diffuse thickening of
the muscularis
propria on
ultrasonography
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15
Q

What is not a clinical complication of a
multiple myeloma?

A. CVA
B. Retinal detachment
C. CKD
D. Hypertrophic
cardiomyopathy
E. Hypercalcemia
F. Thromboembolism
A

F. Thromboembolism

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16
Q

Joey, 6 yo, MN Golden retriever is diagnosed with an
osteosarcoma. The owner wants curative intent. What
are your treatment recommendations?

A. Start him on chemotherapy only
B. Amputate the limb or limb
sparing surgery
C. Amputation/limb sparing +
chemotherapy combination
D. Radiation therapy of the
sarcoma‐stereotactic “gamma
knife”
E. Pain killers including
bisphosphonates– it is a poor
prognosis
A

C. Amputation/limb sparing +

chemotherapy combination

17
Q

f the standard of care is recommended to treat an
osteosarcoma (curative intent), what is the expected cure rate
(2 year survival)

A. 0‐5%
B. 5‐10%
C. 15‐25%
D. 30‐40%

A

C. 15‐25%

18
Q

What is not a prognosticator for OSA in
a dog?

A. Age, > 7 year is worse
B. Location, proximal
humerus is worse
C. ALKP, failure to
decline to normal by
D40 is worse
D. Metastasis, presence
has a shorter MST
A

A. Age, > 7 year is worse

19
Q

‘Petal’ the 12 yo FN Siamese presents with a
mammary mass. What is the first thing you
recommend?

A. FNA
B. Biopsy
C. Radical bilateral, staged
mastectomy
D. Three thoracic
radiographs
E. Coagulation profile
A

D. Three thoracic

radiographs

20
Q

Petal’s MGT: single, left cranial thoracic MG
mass, 4.7 cm diameter, LNN normal size. What is
the correct negative prognosticator?

A. Size: > 4 cm‐bad
B. Tumor type: sarcoma
vs carcinoma
C. MG location: thoracic
good
D. Only one mass‐good
E. N0‐good
A

A. Size: > 4 cm‐bad

21
Q

Pilot, 14 yr, MN, Chow presents with an ulcerated,
swollen mass on his muzzle. FNA confirms it is a MCT.
The owner has very limited funds. What is the best
option for him?

A. Curative intent – surgery,
radiation and
vinblastine/CCNU
B. TKI ‐ toceranib
C. Palliative steroid therapy
with H1 and H2 blockers
D. NSAID and tramadol
E. Doxorubicin single agent
chemotherapy
A

C. Palliative steroid therapy

with H1 and H2 blockers

22
Q

Pilot’s owner one day later decides that she would like to
proceed with definitive treatment for the MCT. The grade is
Patnaik III, or grade II on the 2‐tiered system, c‐kit PCR positive.
What Rx do you recommend after staging?

A. Radiation: LINAC
B. Chemotherapy: CCNU &
vinblastine
C. Chemotherapy: Masivet
D. Surgery/Radiation for
loco‐regional control &
chemotherapy for
distant (L and M) and
long‐term masivet
A 
D. Surgery/Radiation for
loco‐regional control &
chemotherapy for
distant (L and M) and
long‐term masivet
23
Q

What is a specific hematological
feature of hemangiosarcoma?

A. Anemia
B. Heinz bodies
C. Schistocytes
D. Spherocytes
E. Hypochromic RBC
A

C. Schistocytes

24
Q

What is the expected MST in a dog that has had a
splenectomy for hemoabdomen but no follow‐up
chemotherapy?

A. 3 w – 3 m
B. 3 m‐ 6 m
C. 6 m – 12 m
D. 2 years

A

A. 3 w – 3 m

RUSVM Small Animal Medicine 2- A (8 decks)

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